阻塞性睡眠呼吸暂停低通气综合征儿童行为异常与血清C反应蛋白的相关性研究

The relationship between the abnormal behavior and serum C-reactive protein in children with obstructive sleep apnea-hypopnea syndrome

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)儿童行为异常的发病机制。方法:对70例4～11岁打鼾儿童进行整夜多导睡眠仪监测,诊断为OSAHS40例,单纯鼾症30例,并以40例健康儿童为对照组。应用Conners简明症状问卷评定儿童行为问题。采用速率散射比浊法检测以上各组儿童血清C反应蛋白的含量。结果:OSAHS及单纯鼾症组存在行为问题的比率明显高于健康对照组,而两组之间差异无统计学意义。OSAHS组C反应蛋白含量(4.24mg/L)明显高于单纯鼾症组(2.76mg/L)及健康对照组(1.27mg/L);单纯鼾症组C反应蛋白含量高于健康对照组。OSAHS组伴有行为异常者血清C反应蛋白含量(4.63mg/L)明显高于不伴有行为异常者(3.23mg/L);单纯鼾症组伴有行为异常者血清C反应蛋白含量(3.63mg/L)明显高于不伴有行为异常者(1.76mg/L)。结论:OSAHS及单纯鼾症儿童有较多的行为问题出现。C反应蛋白的升高与OSAHS及单纯鼾症儿童的行为异常具有相关性。

Objective：To explore the pathogenesis of abnormal behavior in children with obstructive sleep apnea-hypopnea syndrome（OSAHS）.Method：The behavioral problems and C-reactive protein were measured in 40 children with OSAHS and 30 children with habitual snoring who underwent overnight Polysomnography ,40 cases of healthy children for the control group.Result：The ratio of abnormal behavior in OSAHS and habitual snoring children was significantly higher than that of the healthy control group,while no significant difference between the two groups. The content of C-reactive protein in OSAHS children（4.24 mg/L） was significantly higher than habitual snoring（2.76mg/L） and healthy control group（1.27mg/L）;in habitual snoring children C-reactive protein was higher than in healthy control group. The content of serum C-reactive protein in OSAHS children accompanied by abnormal behavior（4.63 mg/L） was significantly higher than that without abnormal behavior（3.23 mg/L）. The content of serum C-reactive protein content in habitual snoring children accompanied by abnormal behavior（3.63 mg/L） was significantly higher than that without abnormal behavior（1.76 mg/L）.Conclusion：OSAHS and habitual snoring children have more behavior problems. C-reactive protein levels are higher in children with OSAHS and habitual snoring,and the levels of C-reactive protein are related to the abnormal behavior in these children.