810nm激光治疗视网膜分支静脉阻塞的临床研究

Clinical research of 810nm laser for treating branch retinal vein occlusion

目的:探讨应用810nm激光治疗视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)的临床疗效。方法:选择视网膜分支静脉阻塞的患者45例45眼,随机分为治疗组25例25眼和对照组20例20眼,治疗组采用810nm激光治疗,对照组口服复方血栓通胶囊。随访6mo,观察视力、眼底出血吸收情况及眼底荧光血管造影情况。结果:治疗组视力提高13眼,稳定12眼;对照组视力提高2眼,稳定13眼,下降者5眼,治疗组优于对照组;治疗组有22眼视网膜出血吸收明显,3眼出血吸收不明显;对照组有8眼出血明显吸收,12眼出血吸收不明显,治疗组优于对照组;治疗组FFA有效20眼,无效者5眼;对照组FFA有效者9眼,无效者11眼,治疗组优于对照组。结论:810nm激光治疗视网膜分支静脉阻塞能够显著促进出血吸收,稳定和提高视力,防止新生血管产生,可能成为目前治疗视网膜分支静脉阻塞的一种新型有效的治疗方法,但对激光治疗的时机、治疗参数的选择及可能的机制还需进一步探讨。

AIM：To evaluate the therapeutic effect of 810nm laser for the treatment of branch retinal vein occlusion（BRVO）. METHODS： Forty-five cases（45 eyes） suffering from the BRVO were divided into two groups randomly. 25 cases （25 eyes） treated with 810nm laser were taken as treated group; 20 cases （20 eyes） treated with xueshuantong capsule were taken as control group. The patients were followed up for 6 months, and visual acuity, retinal hemorrhage and fundus fluorescein angiography （FFA） were observed. ~ RESULTS= In the treated group, visual acuity improved in 13 eyes, and kept stable in 12 eyes. Retinal hemorrhage was absorbed significantly in 22 eyes, no changes in 3 eyes; the result of FFA was effective in 20 eyes, ineffective in 5 eyes; In control group, visual acuity increased in 2 eyes, kept stable in 13 eyes, and decreased in 5 eyes. Hemorrhage was absorbed significantly in 8 eyes, no changes in 12 eyes. The result of FFA was effective in 9 eyes and ineffective in 11 eyes.CONCLUSION： 810nm laser for the treatment of BRVO can promote the absorption of hemorrhage significantly, stabilize and raise the visual acuity, prevent neovascularization. It may be a novel and effective method to treat the retinal vein occlusion, but the mechanism is unclear and the treatment time and the parameters of laser in treatment should be further studied.