生长激素型垂体腺瘤患者的骨密度研究

Bone mineral density of patients with growth hormone secreting pituitary adenomas

目的:评估中国大陆生长激素腺瘤患者的骨代谢改变并进一步分析其影响因素.方法:选取2007-12/2008-07间于我院就诊的生长激素腺瘤患者23(男9,女14)例和同期的健康对照组244例,对患者组的骨密度改变进行评估.并依据患者术前的激素水平,分析生长激素腺瘤患者术前骨密度的影响因素.结果:生长激素腺瘤患者的骨密度Z值明显高于正常对照组.男性患者组的Z值较对照组明显升高,女性患者组的骨密度Z值的均值虽然高于其相应的对照组,但无统计学差异.Logistic回归分析的结果显示生长激素水平的升高和骨密度增加之间无明显的相关性.性腺功能减退组患者的骨密度Z值的均值低于无性腺功能减退组的患者,但无统计学差异.结论:生长激素腺瘤患者易出现骨密度的增高.其骨密度的改变是多种影响因素共同作用的结果.

AIM：To evaluate the bone metabolic alteration of patients with growth hormone secreting pituitary adenoma（GH adenoma） in Chinese mainland and further to investigate the relevant factors leading to the change of bone mineral density（BMD）.METHODS：Twenty-three patients with GH adenoma（9 men and 14 women） and 244 healthy controls were enrolled in this study between December 2007 and July 2008 and the BMD of the patients were assessed.The hormonal activities of the preoperative patients were analyzed to reveal the influencing factors of BMD.RESULTS：The Z scores of BMD of the patients with GH adenoma were significantly higher than those of corresponding controls.Compared with the Z scores of male controls,the ones of male patients significantly increased.However,there was not a statistical difference of Z scores between female patients and its controls.Logistic regression analysis revealed that there was not a significant correlation between BMD of the patients and serum growth hormone.The mean Z score of hypogonadal group was lower than that of eugonadal group,but no statistical difference existed between them.CONCLUSION：The BMD of patient with GH adenoma often increases,and the interaction of multiple factors is involved in the change of BMD.