子宫内膜癌c-erbB-2和P^(53)基因蛋白表达及其与预后的关系研究

The Expression of c-erbB-2 and P^(53) Oncoprotein in Endometrial Carcinoma and Its Relationship with Clinical Course and Prognosis

采用免疫组织化学法检测了64例子宫内膜癌，16例正常子宫内膜，32例子宫内膜增殖症和5例子宫内膜息肉中的C－erbB-2和P^(53)基因蛋白表达情况并分析与其临床病理和预后的关系。结果：（1）c－erbB-2阳性表达率在内膜癌、内膜增殖症和正常内膜分别为60．9％、21．9％和18．8％。内膜息肉无阳性表达。P^(53)阳性表达率则分别为37．5％。3．l％和0．0％。癌组织与增殖症和正常内膜的c-erbB-2和P^(53)阳性表达率相比较，差异均有显著性（P＜O．05）。（2）内膜组织中的c－erbB-2和P^(53)的阳性表达与临床分期和组织分级有相关性，而与病理类型，肌层浸润无关。（3）P^(53)和。c－erbB－2表达阳性内膜癌患者的3、5年生存率明显低于阴性患者。上述结果表明，c－erbB－2和P^(53)与内膜癌的发生，发展密切相关，可作为评估其恶性生物学行为和预后的重要指标之一。

Expression of c-erbB-2 and p53 oncoprotein was examined by immunohistochemistry in paraffin sections from 64 cases of endometrial carcinoma, 16 cases of noraml endometrium, 32 cases of endometium hyperplasia and 5 cases endometrium polyp. The results showed; (l)The positive rate of expression of c-erbB-2 and P53 in endometrial carcinoma were 60. 9% and 37. 5% respectively. They were significantly higher than normal endometrium, endometium hyperplasia and endometrium polyp.(2)The positive expression of c-erbB-2 and P^(53) in endometrial carcinoma were associated with clinical stage and histologic grade, but not with pathologic type and depth of muscle invasion. (3)The 3 or 5 year survival rate of patient with the positive expressin of c-erbB-2 and P53 were significantly lower than that wilh the negative expression. These results suggested that c-erbB-2 and P53 were valuable maker to understand the dgree of mailigancy and evaluate prognosis of disease.