慢性移植物抗宿主病患者B细胞活化因子变化的研究

Change of B-cell activating factor in patients with chronic graft-versus-host disease

目的探讨B细胞活化因子在异基因造血干细胞移植(allo-HSCT)后慢性移植物抗宿主病(cGVHD)发病机理中的作用。方法观察25例allo-HSCT患者cGVHD的发病情况,cGVHD的诊断主要依据临床表现,部分病例取得病理学依据。移植后定期采集25例患者的外周血,采用流式细胞仪检测B细胞活化因子比例。结果cGVHD阳性组的B细胞活化因子比例明显高于cGVHD阴性组(P<0.01)。结论B细胞活化因子比例在cGVHD发生时明显升高,移植后动态监测B细胞活化因子比例的变化有助于cGVHD的诊治。

Objective To study the role of B-cell activating factor in the pathogenesis of chronic graft-versus-host disease（cGVHD） after allogeneic hematopoietic stem cell transplantation（HSCT）.Methods Occurrence of cGVHD was observed in 25 patients after allogeneic HSCT.cGVHD was clinically diagnosed and histologically confirmed in some patients by biopsy.Peripheral blood was collected from the 25 patients after allogeneic HSCT.B-cell activating factor levels were measured by flow cytometry.Results The ratio of B-cellactivating factor.