正交实验法优化羧甲基-羟乙基淀粉的制备工艺

The Preparation of Carboxymethyl Hydroxyethyl Starch by Orthogonal Design

采用溶媒法以氯乙醇为醚化剂制备羟乙基淀粉,再加入氯乙酸于碱性催化下反应生成羧甲基-羟乙基淀粉。采用正交实验法考查了工艺条件如羟乙基化反应中NaOH的用量、醚化剂2-氯乙醇的用量、反应时间、羧甲基化反应中NaOH的用量、氯乙酸的用量、反应温度对产物取代度的影响,优化了制备工艺。

Carboxymethyl hydroxyethyl starch was made in the condition of alkaline catalysis by putting chloroacetic acid into hydroxyethyl starch which was produced by organic solvent reactions with the 2-chloroethanol as hydroxylating agent. In the preparation,we select the dosage of NaOH（1） ,the dosage of 2-chlorine ethanol,reaction time,the dosage of NaOH（2） ,the dosage of chloroacetic acid and the reaction temperature as the variables,substituting degree as the experiment index,using orthogonal experiment to optimize the preparation process.