吸烟对胃空肠吻合口愈合质量的影响

Clinical Observation of the Influence of Cigarette Smoking on Gastrointestinal Anastomosis

目的评价吸烟对胃空肠吻合口愈合质量的影响。方法将122例因胃手术而行胃空肠吻合的患者,分为不吸烟组41例、戒烟组40例和吸烟组41例。所有患者均行毕II式胃空肠重建,并于术后静注泮妥拉唑40mg每日2次,连续使用7天。所有患者均于手术后3月行胃镜检查,观察吻合口情况。结果不吸烟组、戒烟组、吸烟组吻合口溃疡的发生率分别为7.3%(3/41)、12.5%(5/40)、17.1%(7/41);吻合口炎的发生率分别为9.7%(4/41)、17.5%(7/40)、26.8%(11/41)。3组间吻合口溃疡的发生率方面差异无统计学意义(P>0.05)。不吸烟组与戒烟组以及戒烟组与吸烟组在吻合口炎发生率方面差异无统计学意义(P>0.05)。戒烟组与吸烟组在吻合口炎发生率方面差异无统计学意义(P>0.05)。不吸烟组与吸烟组在吻合口炎发生率方面差异有统计学意义(P<0.05)。结论吸烟对胃空肠吻合口溃疡的发生方面无明显影响,但会增加吻合口炎的发生几率。

Objective To evaluate the effect of smoking on gastrointestinal anastomotic healing quality. Methods 122 cases of gastric surgery for gastrointestinal anastomotic patients were divided into non-smoking group of 41 patients to quit smoking group in 40 cases and 41 cases. All patients underwent complete type II gastrointestinal anastomotic reconstruction, and in postoperative intravenous pantrolazole 40 mg 2 times a day, 7 days of continuous use. All patients were checked-up endoscopy 3 month after the operation to observe the situation anastomosis. Results The incidence of anastomotic ulcer of non-smoking group, quit smoking group, smoking group were 7.3% （3/41）, 12.5% （5/40） and 17.1% （7/41 ）. The incidence of anastomotic inflammation of non-smoking group, quit smoking group, smoking group rates were 9.7% （4/41）, 17.5% （7/40） and 26.8% （11/41）. Among the 3 groups, the incidence of anastomotic ulcer area had no significant difference （P 〉0.05）. Non-smoking groups and smoking cessation group in the incidence of anastomotic inflammation had no significant difference （P 〉0.05）. Smoking cessation group and smoking group in the incidence of anastomotic inflammation had no significant difference （P 〉 0.05）. Non-smoking group and smoking group in the incidence of anastomotic inflammation had significantly difference （P 〈0.05）. Conclusions Smoking can increase the chances of the occurrence ofanastomotic inflammation.