胃癌碱性成纤维生长因子受体的表达与微血管密度的关系及其临床意义

Clinical Significance and Relationship between Basic Fibroblast Growth Factor Receptor and Microvessel Density in Gastric Carcinoma

目的探讨碱性成纤维生长因子受体(bFGFR)与胃癌血管形成以及临床意义。方法选择71例手术切除的胃癌标本为观察组,29例胃癌旁标本为对照组,应用免疫组织化学方法检测组织中bFGFR表达和微血管密度(MVD)。结果bFGFR在胃癌组及对照组中的阳性率分别为50.7%、17.2%,差异有显著性(P<0.01),bFGFR的表达与肿瘤的TNM分期、浸润深度、淋巴及远处转移呈正相关(P<0.05或P<0.01),与肿瘤大小、组织分型、分化程度无关(P>0.05);胃癌组和对照组的MVD分别为45.2±15.2和35.1±5.0,有显著性差异(P<0.05);MVD与肿瘤的TNM分期、浸润深度、淋巴及远处转移有密切相关(P<0.01或P<0.05);胃癌组织中bFGFR阳性的微血管密度高于阴性者,有显著差异(P<0.05)。结论胃癌组织中bFGFR和MVD表达增高,二者可作为胃癌浸润、转移的重要判断指标。

Objective To investigate the relationship between basic fibroblast growth factor receptor （bFGFR） expression and angiogenesis to the clinical significances of gastric cancer. Method Tissues section from 71 gastric carcinoma （GC）, 29 paracareinoma tissues were examined by using immunohistochemistry for the expression of bFGFR and CD34. Results The positive rates of bFGFR was 50.7%, was significantly higher than those ofparacarcinoma tisssues. The high positive expression of this receptor and MVD had significant correlation with regional invasion, clinical grades, lymphatic and blood stream metastasis in GC. But there were no correlation with the size and differentiation degree. Positive of bFGFR and mvd had much higher than those of negative gastric cancer. Conclusion The expression of bFGFR and MVD in GC, two might be significantly correlation with growth, invasion and metastasis of gastric cancer.