米非司酮与孕三烯酮用于子宫内膜异位症术后辅助治疗的比较

Clinical Study on Effect of Mifepristone and Gestrinone as a Subsidiary Treatment after Endometriosis Surgery

目的观察子宫内膜异位症术后药物巩固治疗中米非司酮与孕三烯酮的疗效、不良反应等。方法选择2003年1月至2008年6月在我院行保守(保留子宫)或半保守(保留卵巢)手术治疗的盆腔子宫内膜异位症患者70例,随机分为观察组和对照组,分别服用米非司酮和孕三烯酮,疗程6个月,比较两组的疗效、不良反应、实用性情况。结果两组病人症状均得到不同程度缓解,疗效相似,但米非司酮不良反应明显小于孕三烯酮。结论米非司酮用于盆腔子宫内膜异位症手术后的巩固治疗安全、有效、不良反应小、经济实用,值得农村基层医院推广使用。

Objective To evaluate the effieieney and safety ofmifepristone and gesrrinone in subsidiary treatment after endometriosis surgery. Methods 70 cases of pelvic endometriosis were collected from January 2003 to June 2008 in our hospital, which were randomly divided into two groups, the observation group and the control group, and were treated with mifepristone and gestrinone respectively for 6 months. Compared the efficacy, side effects, practical situation. Result Two groups of patients with symptoms have been eased to varying degrees, efficacy, but side effects of mifepristone was significantly less than of gestrinone. Conclusion Mifepristone in subsidiary treatment after endometriosis surgery was effective on safety and side effects, and economical and practical, which is worth to promote in use of rural grass-root hospitals.