2型糖尿病患者T淋巴细胞活化与颈动脉内中膜厚度的相关性

Association of activation of peripheral T lymphocytes with carotid intima-media thickness in type 2 diabetic patients

目的探讨2型糖尿病患者T淋巴细胞活化与颈动脉内中膜厚度(IMT)的关系。方法121例2型糖尿病患者根据IMT水平分为IMT正常组与IMT增厚和斑块形成组,测定淋巴细胞活化水平、生化指标及基本临床资料。结果 (1)CD3^+HLA-DR^+细胞比率在IMT增厚和斑块形成组显著高于对照组[(11.16±6.88vs6.91±3.33)%,P<0.05],IMT正常组与对照组的差异无统计学意义;(2)偏相关分析显示,CD3^+HLA-DR^+细胞比率与IMT呈正相关;CD3^+HLA-DR^+细胞比率、年龄、SBP为影响颈动脉IMT水平的独立相关因素。结论 T淋巴细胞活化正相关于颈动脉IMT,可能参与T2DM大动脉硬化的发病机制。

Objective To investigate the relationship between the activation of peripheral T lymphocytes and the carotid intima-media thickness （IMT） in type 2 diabetic patients. Methods According to the levels of IMT, a total of 121 patients with type 2 diabetes were divided into two groups： the normal IMT group and the combined thickened IMT and plaque group. The activation of T lymphocytes and the IMT were assessed by flow cytometry and high-resolution B-mode ultrasound respectively. Results The level of CD3＋ HLA-DR^＋ cells in the combined thickened IMT and plaque group was much higher than that in the normal control group [（11.16 ± 6.88 vs 6.91 ± 3.33） %, （P〈 0.05）1. The level of CD3^＋ HLA-DR^＋ cells was associated with the IMT. The IMT of carotid artery in type 2 diabetic patients is positively associated with CD3^＋ HLA-DR^＋ cells, their age, and systolic blood pressure （SBP）. Conclusions These results suggest that the activation of T lymphocytes may play an important role in the pathogenesis of atheriosclerosis in type 2 diabetic patients.