不同糖代谢水平动态血糖谱的差异

The variance of glucose profiles at different stages of glucose metabolism.

目的研究不同糖代谢水平血糖谱差异,以便指导干预时机的选择。方法对糖耐量正常(NGT)、空腹血糖受损(IFG)、餐后血糖受损(IGT)、IFG+IGT及新诊断T2DM患者的72小时动态血糖监测血糖谱进行分析。结果 IFG+IGT组血糖水平及血糖漂移显著高于NGT、IFG、IGT组(P<0.05)。新诊断T2DM组血糖水平显著高于NGT、IFG、IGT、IFG+IGT组(P均<0.05)。新诊断T2DM组餐后及日内血糖漂移与IFG+IGT组无显著差异(P>0.05)。结论 (1)随着糖代谢异常的加重,血糖水平升高,血糖漂移程度增加;(2)IFG+IGT阶段应积极干预。

Objective To investigate the variance of daily glucose profiles at different stages of glucose metabolism so as to instruct the development of rational programs of treatment. Methods The CGMS（continuous glucose monitoring sysytem）data of NGT（nomal glucose tolerance）, IFG（impaired fasting glucose）, IGT（impaired glucose tolerance） ,IFG＋IGT and newly diagnosed T2DM（type 2 diabetes mellitus）were analyzed. Results There was no significant difference between NGT,IFG and IGT in the level of glucose and the degree of glycemic excursion（P〉0. 05）. The level of glucose and the degree of glycemic excursion in IFG plus IGT were significantly higher than those in NGT, IFG and IGT（P〈 0.05）. There was no significant difference between IFG plus IGT and T2DM in the degree of glyeemic excursion（P〉0. 05）. The level of glucose in T2DM was significantly higher than that of other groups（P〈 0. 05）. Conclusions With the aggravation of abnormality of glucose metabolism, the level of glucose becomes higher and the degree of glycemic excursion becomes more serious. Early intervention is suggested on the stage of IFG plus IGT.