湖南省某乡村成年人群中代谢综合征与慢性肾脏病的关系

Metabolic syndrome and chronic kidney disease in a rural adult population of Hunan province, China

目的 研究中国南方某乡村成年人群代谢综合征（MS）和慢性肾脏病（CKD）的关系。方法在湖南省某乡村采用分层多级随机抽样的方法，抽取18岁以上的常住居民1953人，进行MS组分、肾脏损伤指标及其他相关危险因素的问卷调查和检测。结果在资料完整的1709名居民中，用年龄、性别及MS组分校正后，有MS的参与者CKD的患病率比没有MS的参与者高（19.3％vs．13．2％，P〈0．001）。CKD患病率随MS组分数的增多而升高。MS与CKD之间存在强而独立的关联。不合并高血压和糖尿病的参与者，MS也与CKD有关（OR=1．733，95％CI：1．20～2．41，P=0．004）。结论中国南方某乡村1709名研究对象中，MS与CKD存在关联。

Objective To explore the relationship between metabolic syndrome and chronic kidney disease （CKD） in a rural adult population of Hunan province. Methods 1953 residents （older than 18 years） from the same village were randomly selected, using a stratified, multistage sampling method. All residents were interviewed and tested for albuminuria with morning spot urine albumin to creatinine ratio （abnormal： ≥30 mg/g） , reduced renal function with estimated glomerular filtration rate by modified MDRD equation [abnormal： 〈60 ml/min （1.73 m^2） ]. The associations of kidney damage indicators with demographic characteristics （age, gender, smoking status）, indicators on health （diabetes, hypertension） and metabolic syndrome traits were examined. Results Eligible data of 1709 subjects were enrolled in the study. After the adjustment of age, gender and other metabolic syndrome traits, participants with metabolic syndrome had a higher prevalence of CKD （19.3 % vs. 13.2%, P〈0.001 ） than those without the syndrome. As the number of metabolic syndrome traits increased, so did the prevalence of CKD. There seemed to be a strong and independent association between metabolic syndrome and chronic kidney disease. For participants without hypertension and diabetes, metabolic syndrome was also associated with CKD （OR value 1.733,95%CI： 1.20-2.41,P= 0.004）. Conclusion In these 1709 adults under this study from a village of southern China, metabolic syndrome seemed to be associated with CKD.