有效中药复方研究的方法学探讨

Discussion on the Methodology for Studying Clinically Effective TCM Formulas

从化学的角度探讨了临床有效中药复方研究的四个过程 ,简述了直接试验设计在全方药味筛选及化学模式识别中药质量控制中的应用 ,论述了复方有效部位和有效部位中主要有效成分的确定及化学计量学的应用和主要药效物质化学结构信息的计算机模拟方法 ,为中药复方研究提供一个范例。

Four steps in studying clinically effective TCM formulas are discussed on the basis of chemistry. The application of direct experiment design in screening ingredients of a formula, and the adoption of the identification by chemical model in controlling the quality of TCM preparations are briefly recounted. The effective parts of the ingredients of TCM formulas and the determination of the main chemical constituents in them, the application of stechiometry in studying TCM formulas, and computer simulation of the structures of main effective constituents in the ingredients of TCM formulas, are also related in the paper.