山莨菪碱对兔急性肾缺血及再灌注损伤时肾小管超微病理变化的影响

Effect of Anisodamini Hydrobromidum on Renal Tubule Ultrapathological Changes in Acute Ischemic and Reperfusion Injury in Rabbits

用新西兰大白兔制作急性肾缺血及再灌注损伤模型,观察肾小管的超微病理变化及再灌注前给予山莨菪碱片对其变化的影响。结果:再灌注60min组(n=7)兔肾小管超微病理损伤重于缺血60min组(n=7)。山茛菪碱治疗组(n=7)免肾小管的超微病理的损伤明显轻于再灌注60min组,主要表现在肾小管间质水肿减轻,炎性细胞浸润基本消失,肾小管腔面微绒毛排列显著好转。结论:山莨菪碱对急性肾缺血及再灌注损伤时肾小管的超微结构具有保护作用。

The acute ischemic and reperfusion injury models in rabbits were employed to observe the ul-trapathological changes of the renal tubule before and after anisodamini hydrobromidum. The results showed that the ultra pathological lesions in the renal tubule was aggravated in reperfusion group (60 min) as com-pared with the ischemic group (60 min). The ultrapathological lesions in the renal tubule in anisodamini hy-drobromidum-treated group were significantly milder than in the reperfusion group (60 min) .mainly showing edema in renal interstitum abated , nucleated cells infiltrating vanished,and arrangement of the microvilli in re-nal tubule cavity face layer improved. It was suggested that anisodamini hydrobromidum could have protec-tive effects on the ultrastructures of renal tubule in acute ischemic and reperfusion injury.