已酮可可碱治疗急性胰腺炎合并急性肺损伤的实验研究

Experimental Study of Pentoxifylline in Acute Pancreatitis Combined with Acute Lung Injury

目的探讨急性肺损伤的治疗方法。方法建立兔急性肺损伤模型，随机分３组，筛选药物已酮可可碱治疗，检测动脉血气，血清ＴＮＦ－α含量和活性，支气管肺泡灌洗液计数白细胞和白蛋白，肺血管通透性以及肺组织大体和病理观察。结果实验组与模型组比较，血气改善，血清ＴＮＦ－α的含量和活性明显降低，白细胞计数下降，白蛋白含量减低，肺血管通透性下降，肺组织大体明显改善，病理观察损伤肺组织修复；与对照组差异不明显。

Aim To explore a therapeutic method for experimental acute pancreatitis (EAP) combined with acute lung injury (ALI). Methods Rabbit models of acute pancreatitis combined with acute lung injury were randomly divided into the model group (group A), the pentoxifylline group (group B) and the saline solution group (group C). The arterial blood gas and serum TNF α content and activity were analyzed. The neutrophile and polymorphnuclear leukocyte (PMN) in the bronchoalveolar lavage fluid (BALF) and macrophage (MA) were also observed respectively. The albumin content and lung extration were analyzed with the pulmonary microvascular permeability index (PMPI). The surface and histological appearence of lung were observed under microscope and electromicroscope. Results There were more obvious changes in arterial gas, TNF α content and activity, PMN, MA, albumin content, PMPI and the surface and histological appearence of lung in group B than that in group A, and there were no obvious difference in group B and in group C. Conclusion It suggests pentoxifylline can significantly improve the ALI combined with EAP in rabbits.