窄带光成像在膀胱癌早期诊断及复发监测中的应用研究

Application of narrow band imaging in the early diagnosis and recurrent monitoring of bladder cancer

目的探讨窄带光成像(narrow band imaging,NBI)在膀胱癌早期诊断和随访中的作用。方法64例患者,其中48例为初发可疑膀胱癌患者,16例为膀胱癌术后随访患者。采用随机方法分别对同一病例使用普通白光成像(white light imaging,WLI)和NBI进行观察,对可疑病灶标记并进行活检病理学检查。结果本组共46例诊断为膀胱癌,其中34例WLI和NBI均可发现,另12例只能通过NBI发现。WLI诊断灵敏度为78.8%,NBI为100%(P=0.038);WLI诊断假阳性率为27.3%,NBI为23.3%(P>0.05)。结论NBI较WLI对膀胱肿瘤更敏感,有利于早期诊断膀胱肿瘤。

Objective To evaluate the effect of narrow band imaging （NBI） in the early diagnosis and postoperative recurrent monitoring of bladder cancer. Methods 64 consecutive patients were included in this group. Among them 16 had undergone transurethral resection of superficial transitional cell carcinoma and had been followed up and 48 had hematuria. These patients were detected with conventional white light imaging（WLI） cystoscopy and NBI, using the same video-cystoscope. Then all the suspected lesions were biopsied. Results Bladder urothelial carcinoma was confirmed pathologically in 46 cases. 34 were detected by both WLI and NBI and another 12 only by NBI cystoscopy. The sensitivity of WLI vs NBI was 78. 8% vs 100%（P=0. 038）;The false positive rate was 27.3% vs 23.3%（not significant）. Conclusions Sensitivity of NBI was higher than WLI,and NBI could improve sensitivity in the early diagnosis of the bladder cancer.