子宫内膜异位症动物模型活体无创观察研究

Noninvasive Animal Models in Endometriosis Research

子宫内膜异位症(EMs)病因学和治疗学研究需要建立合适的疾病模型,既往对其研究的动物模型通常采用有创观察与病理相结合的研究方法,存在一定缺点。通过总结近5年开展的EMs动物模型活体无创观察方法的研究进展,分析每种方法的原理、方法和应用及相应的优缺点,探讨其改进方向,为EMs的基础研究和临床诊治提供重要观测依据。

The animal model used for studying the etiological and therapeutic aspects of endometriosis needs improvement. Previous studies using invasive observation and pathological anatomy showed many disadvantages. In the article, we reviewed literature over the past five years where non-invasive endometriosis animal models were used. The principle, method and the application of each approach is analyzed. The pros and cons of the various kinds of models are listed, with the addition of suggested improvements of methods. This essential information will benefit basic research and the clinical management of endometriosis.