期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

手性药物的规模化制备方法

Large-scale synthesis of chiral drugs
原文传递
导出
摘要 手性药物的制备对于其研发有着重要的作用。该文综述了现有的大规模合成光学纯药物或关键中间体的方法,举实例说明各方法需要解决的关键问题,并重点讨论了化学催化的不对称合成。 The preparation of chiral drugs plays an essential role in their research and development. This review summarized advance in the large-scale preparation of optically pure drugs or their key intermediates. Key issues for opplication of these methods were also discussed with practical examples, with an emphasis on chemo-catalyzed asymmetric synthesis.
作者 张学丽 孙宏斌
机构地区 中国药科大学新药研究中心
出处 《中国药物化学杂志》 CAS CSCD 2009年第6期486-497,共12页 Chinese Journal of Medicinal Chemistry
关键词 不对称合成 规模化合成 手性药物 asymmetric synthesis large-scale synthesis chiral drug
分类号 R914 [医药卫生—药物化学]
  • 相关文献

参考文献40

  • 1戴立信,陆熙炎,朱光美.手性技术的兴起[J].化学通报,1995(6):15-22. 被引量：57
  • 2FARINA V, REEVES J T, SENANAYAKE C H, et al. Asymmetric synthesis of active pharmaceutical ingredients[ J]. Chem Rev, 2006, 106 (7) : 2734 - 2793.
  • 3BLASER H U,PUGIN B, SPINDLER F. Progress in enantioselective catalysis assessed from an industrial point of view[ J]. J Mol Catal, 2005, 231 (1/2) : 1 -20.
  • 4ROUHI A M. Traditional methods thrive despite numerous hurdles, including tough luck, slow commercialization of catalytic processes [ J ]. Chit Chem, 2004,82(24) :47 - 62.
  • 5HAUCK W, ADAM P, BOBIER C, et al. Use of large-scale chromatography in the preparation of armodafinil [ J ]. Chirality ,2008,20 ( 8 ) :896 - 899.
  • 6PFLUM D A,WILKINSON H S ,TANOURY G J,et al. A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC[ J]. Org Process Res Dev,2001,5(2) :110 - 115.
  • 7NATH ROY B, PAL SINGH G, SRIVASTAVA D, et al. A novel method for large-scale synthesis of lamivudine through cocrystal formation of racemic lamivudine with ( S ) -( - ) -1, 1 '-bi ( 2-naphthol ) [ (S)-(BINOL) ] [J]. Org Process Res Dev,2009, 13(3) :450-455. SANJOG R, CHANDRAKANT S T, MOHANLAL P J,et al. Process for the preparation of optically pure indeno [5,4-b ] furan derivatives: WO, 2008/062468 [ P]. 2008 - 05 - 29.
  • 8SANJOG R, CHANDRAKANT S T, MOHANLAL P J,et al. Process for the preparation of optically pure indeno [ 5,4-b ] furan derivatives: WO, 2008/062468 [ P]. 2008 - 05 - 29.
  • 9蒋龙,夏正君,陈再新,姚成.雷美替胺的合成[J].中国医药工业杂志,2009,40(3):161-164. 被引量：13
  • 10ELATI C R, KOLLA N, VANKAWALA P J, et al. Substrate modification approach to achieve efficient resolution: didesmethylcitalopram: a key intermediate for escitalopram [ J 1. Org Process Res Dev, 2007,11 (4) :289-292.

二级参考文献13

  • 1黄玉凤,唐丽娜.新型催眠药瑞美替昂及其临床研究[J].世界临床药物,2006,27(9):556-559. 被引量：9
  • 2Uchikawa O, Fukatsu K, Tokunoh R, et al. Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists [J]. J Med Chem, 2002, 45(19): 4222-4239.
  • 3Yamano T, Yamashita M, Adachi M, et al. Approach to the stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric hydrogenation [J]. Tetrahedron: Asymmetry, 2006, 17 (2) : 184-190.
  • 4Yamano T, Adachi M, Kawada M. Production of optically active compound: JP, 11080106 [P]. 1999-03-26. (CA 1999, 130: 252236)
  • 5Imai T, Miura T, Unrin H, et al. Production of optically active amine derivative: JP, 11140073 [P]. 1999-05-25. (CA 1999, 131: 44725)
  • 6Urayama S, Mutou E, Inagaki A, et al. Process for production of optically active amine derivatives: WO, 2006030739 [P]. 2006-03-23.
  • 7Ashton PR, Girreser U, Giuffrida D, et al. Molecular belts. 2. Substrate-directed syntheses of belt-type and cage-type structures [J].JAm Chem Soc, 1993, 115 (13) : 5422-5429.
  • 8Lai J Y，J Org Chem，1993年，58卷，6944页
  • 9Gu J X，Tetrahedron，1993年，49卷，5805页
  • 10匿名著者，化学，1993年，48卷，642页

共引文献68

中国药物化学杂志
2009年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部