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急性乙醇中毒对大鼠纹状体MDA和SOD的影响及吡拉西坦的保护作用

Study on Effect of Acute Alcoholism on MDA and SOD in the Striatum of Rats and the Protection of the Piracetam
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摘要 目的观察急性乙醇中毒对大鼠纹状体丙二醛(malondialdehyde,MDA)和超氧化物歧化酶(superoxidedismutase,SOD)的影响以及吡拉西坦的保护作用。方法选雄性Wistar大鼠30只,随机分为对照组、模型组、吡拉西坦组,测定各组纹状体MDA和SOD的变化。结果与对照组相比,模型组大鼠纹状体MDA含量显著升高,SOD活性则显著降低。吡拉西坦组与模型组相比,MDA含量显著降低,SOD活性则显著升高。结论大鼠急性乙醇中毒后表现出明显的氧化损伤,而吡拉西坦对于这种氧化损伤具有一定的保护作用。 Objective To observe the effect of acute alcoholism on the malondialdehyde (MDA) and superoxide dismutase (SOD) in the striatum of rats and the protection of piracetam. Methods Thirty healthy adult male Wistar rats were selected and randomly divided into three groups : the control group, model group, and piracetam group. To observe the change of the MDA level and the SOD activity in striatum in each group. Results Compared with the control with acute alcoholism.
出处 《潍坊医学院学报》 2009年第5期381-383,共3页 Acta Academiae Medicinae Weifang
基金 潍坊市科技局资助课题[课题编号:潍科字(2003)第101号]
关键词 乙醇中毒 急性 吡拉西坦 丙二醛 超氧化物歧化酶 大鼠 Acute alcoholism Piracetam Malondialdehyde Superoxide dismutase Rats
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  • 1Winblad B. Piracetam:a review of pharmacological properties and clinical uses[J]. CNS Drug Rev,2005,11 (2) :169 - 182.
  • 2Lester AR. Spintrapping evidence for alcohol-associated oxidativestress [J]. Free Radical Biol Med,2002,32(10 ) :953 -957.
  • 3Abraham P, Wilfred G, Ramakrishna B. Oxidative damage to the hepato cellular proteins after chronic ethanol intake in the rat [ J ]. Clinica Chimica Acta,2002,325(1-2) :117 - 125.
  • 4Arthur IC ,Wu DF, Mari M, et al. CYP2E1 -dependent toxicity and oxidative stress in HepG2 cells[ J]. Free Radical Biol Med,2001,31 (12) :1539 - 1543.
  • 5Stoll L, Schubert T, Muller WE. Age-related deficits of central muscafinic cholinergic receptor function in the mouse : partial restoration by chronic piracetam treatment[ J]. Neurobiol Aging, 1992,13 ( 1 ) : 39 - 44.
  • 6Winnicka K,Tomasiak M, Bielawska A. Piracetam--an old drug with novel properties[ J] ? Acta Pol Pharm,2005,62(5 ) :405 -409.
  • 7Genton P, Van Vleymen B. Piracetam and levetiracetam:close structural similarities but different pharmacological and clinical profiles [ J ]. Epileptic Disord, 2000,2 ( 2 ) : 99 - 105.
  • 8孙成春,王景祥,陈冬梅.吡拉西坦对小鼠脑内MDA和SOD含量的影响[J].山东医药工业,1996,15(1):36-36. 被引量:2

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