窄谱中波紫外线治疗对银屑病患者血清肿瘤坏死因子α水平的影响被引量：1

下载PDF

导出

摘要目的探讨窄谱中波紫外线(NB-UVB)治疗银屑病的作用机制。方法对50例寻常型银屑病患者进行NB-UVB照射治疗,并检测治疗前后血清肿瘤坏死因子α(TNF-α)水平,另选40名志愿者作为健康对照组。结果银屑病患者血清TNF-α水平显著高于健康对照组,经NB-UVB照射治疗后,其血清TNF-α水平明显降低,且差异具有显著性。结论 NB-UVB治疗银屑病的作用机制包括降低其炎性介质(如TNF-α)。

作者赵学良单秀娟王辉

机构地区潍坊医学院附属潍坊市人民医院皮肤科

出处《潍坊医学院学报》 2009年第5期393-394,共2页 Acta Academiae Medicinae Weifang

基金潍坊市卫生局科研项目(2008008)

关键词银屑病紫外线肿瘤坏死因子Α

分类号 R751.05 [医药卫生—皮肤病学与性病学]

引文网络
相关文献

参考文献11

1Dawe RS, Wainwright N J, Cameron H, et al. Narrow-band ultraviolet B phototherapy for chronic plaque psoriasis: three times or five times weekly treatment [ J ]. Br J Dermatol, 1998,138 (5) :833 - 839.
2Kristensen M, Chu CQ, Eedy D J, et al. Localization of tu-mour necrosis factor-alpha(TNF-α)and its receptors in nor-mal and psoriatic skin: epidermal ceils express the 55-kDbut not the 75-kD TNF receptor[ J]. Clin Exp Immunol,1993 ,94( 2 ) :354 -362.
3张春玲,谢志宏,贾青,金祖余.银屑病患者血清中细胞因子TNFα和IL-6测定[J].临床皮肤科杂志,2000,29(5):276-277. 被引量：12
4Waiters IB, Burack LH, Coven TR, et al. Suberythemogenic nar-rowband UVB is markedly more effective than conventional UVB intreatment of psoriasis vulgaris [ J ]. J Am Acad Dermatol, 1999,40 ( 11 ) : 893 - 900.
5崔欣,张恩虎.窄谱中波紫外线治疗银屑病的机制与临床应用[J].中国皮肤性病学杂志,2004,18(11):690-691. 被引量：10
6Piskin G, Sylva-Steenland RM, Bos JD, et al. T cells in psoriat-ic lesional skin that survive conventional therapy with NB-UVBradiation display reduced IFN-gamma expression [ J ]. Arch Der-matol Res,2004, 295(12) :509 -516.
7Waiters IB, Ozawa M, Cardinale I, et ai. Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin(IL) 12 and increases IL-4 transcripts:differential regulation of cytokines at the single-cell level [J] .Arch Dermatol,2003,139(2) :155 - 161.
8Ozawa M, Ferenczi K, Kikuchi T, et al. 312-nanometer ultravi-olet B light ( narrow-band UVB ) induces apoptosis of T cellswithin psoriatic lesions [ J ]. J Exp Med, 1999,189 ( 4 ) :711 - 718.
9Lehmann B, Knuschke P, Meurer M. Effect of UVB radiationemitted from the narrowband TL-01 lamp ( 311 nm) onthecal-citriolsynthesisinorganotypicculturesotkeratinocytes [ J ]. ExpDermatol, 2005,14 ( 2 ) : 153.
10Ameglio F, Bonifati C,Pietravalle M, et al. Interleukin-6and tumour necrosis factor levels decrease in thesuctionblister fluids of psoriatic patients during effective therapy [ J ]. Dermatology, 1994, 189 ( 4 ) : 359 - 363.

二级参考文献16

1秦建中张学军等.银屑病的免疫病理机制.现代皮肤性病学进展[M].合肥市:安徽科学技术出版社,1997.355-395.
2秦建中，现代皮肤性病学进展，1997年，355页
3Krutmann J,Morita A.Mechanisms of ultraviolet (UV) B and UVA phototherapy[J].J InvestigDermatol Symp Proc,1999,4(1):70-72.
4el-Ghorr AA,Norval M,Lappin MB,et al. The effect of chronic low-dose UVB radiation on Langerhans cells, sunburn cells,urocanic acid isomers,contact hypersensitivity and serum immunoglobulins in mice[J].Photochem Photobiol,1995,62(2):326-632.
5Guckian M,Jones CD,Vestey JP,et al.Immunomodulation at the initiation of phototherapy and photochemotherapy[J].Photodermatol Photoimmunol Photomed,1995,11(4):163-169.
6de Rie MA,Out TA,Bos JD.Low-dose narrow-band UVB phototherapy combined with topical therapy is effective in psoriasis and does not inhibit systemic T-cell activation[J].Dermatology,1998,196(4):412-417.
7Gloor M,Scherotzke A.Age dependence of ultraviolet light-induced erythema following narrow-band UVB exposure[J].Hotodermatol Photoimmunol Photomed, 2002,18(3):121-126.
8Tzung TY, Runger TM. Assessment of DNA damage induced by broadband and narrowband UVB in cultured lymphoblasts and keratinocytes using the comet assay[J].Photochem Photobiol,1998,67(6):647-650.
9van Prooijen HC,van Marwijk Kooy M,van Weelden H,et al.Evaluation of a new UVB source for irradiation of platelet concentrates[J].Br J Haematol,1990,75(4):573-577.
10Walters IB,Burack LH,Coven TR,et al.Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris[J].J Am Acad Dermatol, 1999,40(6 Pt 1):893-900.