TNF-α和TGF-β1在急性有机磷中毒中的临床意义

Clinical significance of TNF-α and TGF-β1 in acute organophosphorus pesticid poisoning

目的:探讨TNF-α和TGF-β1在急性有机磷农药中毒(AOPP)中的临床意义。方法:选取既往健康的急性中毒患者42例,分别于来院即刻抽静脉血,保存至采用放免分析法同批测定血清中TNF-α、TGF-β1含量,与20例健康献血者对照,比较不同病情患者血清中TNF-α、TGF-β1含量,不同预后患者血清中TNF-α、TGF-β1含量及TGF-β1/TNF-α比值。结果:急性药物中毒患者血清TNF-α、TGF-β1明显升高,随病情加重增加更明显,死亡组患者TGF-β1/TNF-α失衡患者比例高于存活组。结论:在AOPP时,机体同时存在促炎反应和抗炎反应,炎症介质和抗炎介质的过度释放及二者平衡失调是AOPP引发多器官功能障碍综合征(MODS)的重要发病机制之一。

AIM： To study the clinical significance of TNF-a and TGF-β1 in acute organophosphorus pesticid poisoning. METHODS： All acute drug poisoning cases enrolled were 42, who were all healthy before poisoning. Conserve the blood serum. Deploying radio immunoassay to determine the levels of TNF-α and TGF-β1. Compare the levels of TNF-α and TGF-β1 between poisoning group and health control group（20 cases）, compare the levels of TNF-α and TGF-β1 and TGF-β1/TNF-α in of poisoning cases of different prognosis. RESULTS： The levels of TNF-α and TGF-β1 in poisoning group were higher than those of control group, the difference between them was significant （P 〈 0.01）. The more severer was the patient＇s condition, the higher were the levels of TNF-α and TGF-β1, the rate of TGF-β1/TNF-α different from control group in death group was evident higher then those of survive group. CONCLUSION： SIRS/CARS play an important role in the process of MODS induced by AOPP; TGF-β1/TNF-α ratio can reflect the immunne state of the organism and can be an reference index of balance of SIRS/CARS.