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解整合素-金属蛋白酶33与支气管哮喘 被引量：4

ADAM33 and bronchial asthma
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摘要 ADAM33是一种新近发现的解整合素-金属蛋白酶(adistintegrin and metalloproteinase,ADAM)家族成员。部分研究认为,其基因多态性与气道高反应性和气道重塑相关,该基因突变表达后能够影响肺功能从而使之与哮喘产生强烈的相关性,而部分学者的研究后却并不认同这个观点,并且对于不同种族人群的ADAM33和哮喘的关系的研究中得出了许多不一致的结论。该文就这两种意见进行综述,以便能更全面地了解ADAM33基因的功能及其对支气管哮喘的作用,有助于从新的角度研究支气管哮喘的发病机制。 ADAM33 is a newly identified member of a distintegrin and metalloproteinase ADAM family. Some studies have confirmed its polymernbisms involved in bronchial hyperresponsiveness and airway remodeling. The expression of mutated gene can accelerate decline of pulmonary function so that it is closely associated with asthma. But other studies have disclosed conflicting results and different results were found from different ethnic populations. This article reviewed these two different issues to help our better understanding of the role of ADAM33 and its association with asthma,facilitating studies on the pathogenesis of asthma from a new perspective.
作者 袁方 张建华
机构地区 上海交通大学附属第六人民医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2009年第12期1187-1189,共3页 Journal of Clinical Pediatrics
关键词 解整合素金属蛋白酶33 支气管哮喘 单核苷酸多肽性 ADAM33 bronchial asthma single nucleotide polymorphisms
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献20

  • 1Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness [J]. Nature ,2002,418(6896) :426-430.
  • 2Cheng L, Enomoto T, Hirota T, et al. Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen [J]. Clin Exp Allergy,2004,34(8) :1192-1201.
  • 3Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics [ J ]. Clin Exp Allergy, 2004,34 (6) : 860-865.
  • 4Werner M, Herbon N, Gohlke H, et al. Asthma is associated with single-nucleotide polymorphisms in ADAM33 [J]. Clin Exp Allergy, 2004,34 ( 1 ) : 26-31.
  • 5Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population [J]. J Hum Genet ,2007,52 (1):66-72.
  • 6Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population [J]. Clin Exp Allergy,2006,36(7):884-891.
  • 7Jongepier H, Boezen HM, Dijkstra A, et al. Polymorphisms of the ADAM 33 gene are associated with accelerated lung function decline in asthma [J]. Clin Exp Allergy,2004,34(5):757-760.
  • 8Ito I, Laporte JD, Fiset PO, et al. Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells [J ]. J Allergy Clin Immunol, 2007,119 (1): 89-97.
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  • 10Foley SC, Mogas AK, Olivenstein R, et al.Increased expression of ADAM33 and ADAM8 with disease progression in asthma [J]. J Allergy Clin Immunol,2007,119(4) :863-871.

二级参考文献8

  • 1Wolfsberg TG, Primakoff P, Myles DG, et al. ADAM a novel family of membrane proteins containing a disintegrin and metalloprotease domain; multipotential functions in cell-cell and cell-matrix interactions[J]. J Cell Biol, 1995, 131(2) 275-8.
  • 2Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity[J]. Gene, 2002, 282(1-2): 227-36.
  • 3Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness [ J ].Nature, 2002, 418(6896): 426-30.
  • 4Chae SC, Yoon KH, Chung HT. Identification of novel polymorphisms in the ADAM33 gene [J]. J Hum Genet, 2003, 48 (5):278-81.
  • 5Werner M, Herbon N, Gohike H, et al. Asthma is associated with single-nucleotide polymorphisms in ADAM33 [J]. Clin Exp Allergy, 2004, 34(1): 26-31.
  • 6Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics [J].Clin Exp Allergy, 2004, 34(6): 860-5.
  • 7Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population [J].Clin Exp Allergy, 2006, 36(7): 884-91.
  • 8中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138. 被引量：3562

共引文献4

同被引文献55

  • 1揭志军,蔡映云.一种新的哮喘易感基因——ADAM33基因[J].国外医学（呼吸系统分册）,2005,25(9):647-649. 被引量：4
  • 2Wolfsberg TG, Primakoff P, Myles DG, et al. ADAM a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions( J ). J Cell Biol, 1995,131:275-278.
  • 3Primakoff P, Myles DG. The ADAM gene family:surface protein with adhesion and protease activity[ J ].Trends Genet,2000,16 : 83-87.
  • 4Van Eerdewegh P,Little RD,Dupuis J,et al.Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness [J]. Nature, 2002,418 : 426-430.
  • 5Drazen JM, Weiss ST. Genetics: inherit the wheeze [J]. Nature, 2002, 418:383-384.
  • 6Umland SP, Garlisi CG, Shah H, et al. Human ADAM33 messenger RNA expression profile and post-transcriptional regulation [J].Am J Respir Cell Mol Biol, 2003, 29:571-582.
  • 7Dijkstra A, Postma DS, Noordhoek JA, et al. Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung [J]. Virchows Arch, 2009,454:441-449.
  • 8Haitchi HM, Bassett D J, Bucchieri F, et al. Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy (J). J Allergy Clin Immunol, 2009,124:590-597.
  • 9Lee JY, Park SW, Chang HK, et al.A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation [J]. Am J Respir Crit Care Med, 2006,173:729-735.
  • 10Puxeddu I, Pang YY, Harvey A, et al. The soluble form of a disintegrin and metallop rotease 33 promotes angiogenesis: Implications for airway remodeling in asthma[J]. J Allergy Clin Imm unol, 2008, 121:1400 -1406.

引证文献4

二级引证文献9

临床儿科杂志
2009年 第12期

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