高血压患者炎性因子表达水平及奥美沙坦对炎性因子的影响

Expression of inflammatory factors in hypertension and influence of olmesartan on inflammatory factors

目的:探讨高血压和炎症的关系以及评价奥美沙坦在有效降压的同时是否具有抗炎作用。方法:轻、中度高血压患者60例及健康体检者60例,用ELISA方法测定血清超敏C反应蛋白、sCD40L的水平。高血压组患者给予奥美沙坦20～40mg/d,服药8周后重复测定以上所有指标。结果:轻、中度高血压患者血清超敏C反应蛋白、sCD40L水平明显高于对照组,差异有统计学意义(P<0.05)。高血压组用药后超敏C反应蛋白、sCD40L明显下降。结论:高血压是一种慢性血管炎症性疾病,奥美沙坦在有效降压的同时具有抗炎作用。

Objective To observe the changes of inflammatory factors in hypertensive patients,and estimate whether olmesartan has anti-inflammatory action.Methods Sixty patients with mild to moderate hypertension,60 normal subjects were measured high sensitivity C-reactive protein and sCD40L with ELISA.All patients received olmesartan 20 to 40 mg once a day,for totally 8 weeks and were evaluated again.Results After 8 weeks＇ treatment,olmesartan reduced blood pressure.There was a significant increase in serum high sensitivity C-reactive protein and sCD40L in hypertensive patients compared with the controls.Conclusion Hypertension is a kind of vascular inflammatory disease.Olmesartan has anti-inflammatory and anti-hypertension effect.