牛黄酸对应激大鼠心功能异常变化及心肌损伤的保护作用

THE PROTECTIVE EFFECTS OF TAURINE AGAINST ABNORMAL CHANGES OF CARDIAC FUNCTION AND MYOCARDIAL INJURY IN RATS UNDER EXPERIMENTAL STRESS

以异丙肾上腺素（Ｉｓｏ）诱导的大鼠应激为模型，无创性地研究牛磺酸（Ｔａｕ）对心功能异常变化及心肌损伤的保护作用。与试验前比较，试验后Ｉｓｏ组ＨＲ、ＨＩ、ＣＯ、Ｃ波显著降低，ＲＲ、ＱＳ２、ＰＥＰ、ＺＯ、ＦＴ均显著升高，Ｔａｕ＋Ｉｓｏ组及对照组心功能参数未见显著变化，且Ｉｓｏ组试验后心肌组织有明显损伤，主要表现为肌纤维肿胀、断裂及竹节状病变，而牛磺酸组及对照组试验后心肌组织无显著变化。结果提示，牛磺酸可显著拮抗大鼠的应激性心律失常及心肌收缩、舒张功能的降低。

Isoproterenol (Iso) induced acute stress on Wistar rats as model and the protective effects of taurine (Tau) on cardiac function and against pathological changes of myocardium were studied. The results showed that as compared with initial period of experiment, the cardiac functional parameters such as RR,QS 2, PEP, ZO and FT were significantly increased, but HR, HI, CO and C-wave were significantly reduced in Iso group. As for taurine and control groups,except for HI, other parameters were not changed significantly. The pathological examination of Iso group showed that myocardium was injured accompanied by swelling and break or necrosis of myocardial fiber. There were no significant pathological changes for taurine and control group. It suggested that taurine can protect stressed rats from myocardial injury, arrhythmia and impairment of systolic and diastolic function.