砷的分子毒理学研究进展

Recent Development of Scientific Researches on Molecular Toxicology of Arsenic

近年来，砷化合物对生物大分子合成和代谢、对基因扩增和表达、以及对ＤＮＡ损伤和修复等影响效应的研究进展迅速，形成了砷生物学作用研究的一个新的领域－砷的分子毒理学。现就此方面的研究进展情况综述如下。１砷化合物对生物大分子合成的效应１．１砷与细胞ＤＮＡ合成...

Abstract The recent development of scientific researches on Molecular Toxicology ofarsenic is briefly reviewed.The main contents of this paper include;(1)Effects of arsenic on synthesis of large biological molecules,including studies on rates of synthesis of DNA,RNA,proteins,and heat shock proteins,and accuracy of DNA synthesis,and hydrolysis of proteins,and so on;(2)Effects of arsenic on DNA damage and repair,emphasizing investigations on effects of arsenc in E.coli and in human cells;(3)The newest studies on effects of arsenic on gene amplification and blast transformation of human lolld lymphocytes.We suggest that arsenic might be a necessary biological super-trace element for lief,and further studying this problem is needed.