病毒性心肌炎分期和病情程度对血清TNF-α及T淋巴细胞亚群的影响

VARIANT OF T LYMPHOCYTE SUBSETS AND SERUM TUMOR NECROSIS FACTOR OF CHILDREN WITH VIRAL MYOCARDITIS

观察了６８例小儿病毒性心肌炎外周血Ｔ淋巴细胞亚群和血清肿瘤坏死因子α（ｓＴＮＦα）的变化。结果发现急性期患儿ＣＤ３、ＣＤ４和ＣＤ４／ＣＤ８值明显降低，病情重者降低更明显，而迁延及慢性期患儿仅表现ＣＤ４／ＣＤ８值异常。同时还观察到ｓＴＮＦα在急性期、迁延及慢性期增高，病情程度越重，ｓＴＮＦα的水平就越高，与恢复期和对照组比较有明显差异，Ｐ＜００５，提示细胞免疫功能紊乱与病毒性心肌炎的发病以及病情程度有一定关系。

The level of T lymphocyte subsets in peripheral blood and tumor necrosis factorα in serum of 68 cases with viral myocarditis(VMC) were monitored.The results showed that CD3,CD4 and CD4/CD8 of acute cases were decreased and CD4 was not decreased significantly,but CD4/CD8 was still lower on persistent and chronic cases.Mean while the severer the condition of VMC,the lower the CD4 cells and CD4/CD8.The results showed that the tumor necrosis factor was increased on acute,persistent and chronic cases and had statistical difference when compared with normal control and recovering cases.The level of tumor necrosis factor was associated with severity of VMC.So it suggested that cellular immunity may play a role on pathogenesis and severity of VMC.