上海市长宁区2008年麻疹-流行性腮腺炎-风疹联合减毒活疫苗接种后不良事件监测分析

Surveillance of Adverse Events Following Immunization of MMR in Changning District of Shanghai,2008

目的分析上海市长宁区2008年麻疹-流行性腮腺炎-风疹联合减毒活疫苗(Measles,Mumps,RubellaCombined Attenuated Live Vaccine,MMR)预防接种不良事件(Adverse Events Following Immunization,AEFI),研究监测的有效模式,为建立规范化预防接种安全监测体系提供依据。方法以MMR作为监测疫苗,采用主动监测与被动监测相结合的方法开展AEFI监测研究。结果收集AEFI报告95例,多为一般反应;主动监测模式获得的AEFI信息明显多于被动监测;各级疾病预防控制中心建立了信息沟通交流机制。结论主动与被动相结合的监测模式,可提高AEFI报告的敏感性和利用率。

Objective To summarize the adverse events of Measles, mumps, rubella combined attenuated live vaccine （MMR） during 2008 in Changning District of Shanghai. To research the effective monitoring pattern of adverse event following immunization （AEFI）, and to provide evidence for establishing the safe monitoring system. Methods Using MMR as the surveillance vaccine,the AEFI monitoring research with the active and passive methods was implemented. Results 95 reports were collected. Most of the adverse events were common. The imformation from the active method was more than the imformation from the passive method. It was established the communication mechanism of the Centers for Disease Control and Prevention （CDC） between the different levels. Conclusion Active and passive methods will improve the susceptibility and the utilization rate of data reporting.