上海市流行性乙型脑炎流行病学分析

Epidemiological Characteristics of Japanese Encephalitis in Shanghai

目的掌握上海市流行性乙型脑炎(乙脑)流行现状和流行病学特征,为有效预防控制乙脑提供依据。方法采用描述流行病学、血清学和分子生物学方法,分析上海市乙脑流行病学特征、健康人群抗体水平、中间宿主猪的感染状况等。结果上海市2006年乙脑发病率为0.129/10万,2007年为0.077/10万;流行前期健康人群乙脑抗体阳性率为60.39%,流行后期为85.44%。中间宿主3月龄肉猪IgG抗体抗体阳性率为26.92%;上市屠宰肉猪抗体阳性率为14.86%。媒介蚊中检测到的乙脑病毒为基因1型。结论上海市乙脑发病处于较低水平,健康人群乙脑抗体阳性率较高,中间宿主猪中存在乙脑病毒感染,蚊虫乙脑病毒基因分型为1型。

Objectives To understand the epidemiological characteristics of Japanese Encephalitis in Shanghai and to provide evidence for preventing JE. Methods Epidemic characteristics, JEV antibody in healthy population and swine infection rate in Shanghai were analyzed by methods of field survey, serology and molecular biology. Results JE incident rate in Shanghai was 0.077/100,000 in 2006; and 0.129/100,000 in 2007. Antibody positive rate before JE epidemic fastigium was 60.39%; postive rate after epidemic was 85.44%. JE IgG positive rate was 26.92% in 3-month swine and 14.86% in swine for sale; JE Gene in mosquito was analyzed for type 1. Conclusion The JE prevalence rate is relatively low in Shanghai. JE antibody positive rate is high in Shanghai population. Swine as a media is infected by JE virus. The JE virus in mosquitoes belongs to genotype 1.