摘要
为了解丙烯腈和乙醇是否具有联合毒性作用，用灌胃染毒的方法探讨乙醇在非毒性剂量条件下丙烯腈对肝脏及外周血液毒性的影响。结果表明：乙醇能加重和加速丙烯腈的肝脏和外周血液毒性，主要表现为：（１）肝细胞功能减退、结构破坏。２）外周血白细胞总数及分类细胞数明显减少，其中以淋巴细胞数目减少最明显。因此认为：在肝脏和血液毒性方面丙烯腈和乙醇具有联合作用。
In order to learn the joint effects of acrylonitrile and alcohol, acrylonitrile(40μg/g), alcohol (1000μg/g) and the mixed liquid of the both (40, 1000μg/g) were given to rats by gavage for 8 weeks. The results revealed the joint effects of acrylonitrile and alcohol. Hypofunction and structural lesion of hepatocyte were found in the rats. The numbers of white blood cells decreased remarkably in these two groups.
出处
《卫生研究》
CAS
CSCD
北大核心
1998年第5期295-296,共2页
Journal of Hygiene Research
关键词
丙烯腈
乙醇
联合毒性
肝脏
毒性
职业危害
\ acrylonitrile,\ alcohol,\ combined effect,\ liver,\ blood
