女性压力性尿失禁患者阴道壁组织中MMP-13、MMP-14和TIMP-1的表达变化及意义被引量：2

Expression and significance of MMP-13,MMP-14 and TIMP-1 in vaginal wall tissue of women with stress urinary incontinence

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摘要目的探讨女性压力性尿失禁(SUI)患者阴道壁组织中基质金属蛋白酶13、14(MMP-13、14)和组织基质金属蛋白酶抑制剂-1(TIMP-1)的表达变化及意义。方法收集30例女性SUI患者的阴道壁组织(SUI组)、30例盆腔器官脱垂患者(POP)的阴道壁组织(POP组)、30例无SUI及POP患者的阴道壁组织(对照组),采用免疫组化SP法检测这三组的MMP-13、MMP-14、TIMP-1。结果MMP-13、MMP-14在POP组、SUI组中的表达明显高于对照组(P均<0.05),TIMP-1在POP组、SUI组的表达明显低于对照组(P均<0.05);SUI组MMP-13的表达与TIMP-1表达呈负相关(r=-0.281,P<0.05),MMP-14与TIMP-1的表达呈负相关(r=-0.381,P<0.05),MMP-13与MMP-14的表达呈正相关(r=0.992,P<0.05)。结论女性SUI患者阴道壁组织中MMP-13、14表达增加,TIMP-1表达减少,导致胶原降解增加,从而诱发SUI。 Objective To detect the expression and significance of matrix metalloproteinase-13（MMP-13）,MMP-14 and tissue inhibitor of matrix metallop roteinase-1（TIMP-1）in the vaginal wall tissue of the women with stress urinary incontinence（SUI）.Methods Biopsy specimens of vaginal wall tissue were obtained from 30 patients with SUI,30 patients with POP,30 patients without SUI and POP as control group.Immunohistochemical technique were applied to detect the MMP-13,MMP-14 and TIMP-1.Results MMP-13 and MMP-14 were significantly higher in group SUI and group POP than that in control group（P0.05）.TMIP-1 was significantly lower（P0.05）in both group SUI and group POP than in control group（P0.05）.The difference of MMP-13,MMP-14 and TIMP-1 between group SUI and POP has no significance（P0.05）.There were negative relationship between the expression of TIMP-1,MMP-13 and MMP-14 in SUI group（r=-0.281,P0.05;r=-0.381,P0.05）,there was positive relationship between the expressions of MMP-13 and MMP-14 in SUI group（r=0.992,P0.05）.Conclusion The increasing of MMP-13 and MMP-14 and the decreasing of TIMP-1 may cause the degradation of collagen in total.It may play an important role in the development of SUI.

作者冯未萍王鲁文刘丽萍

机构地区郑州大学第三附属医院

出处《山东医药》 CAS 北大核心 2009年第42期26-27,共2页 Shandong Medical Journal

基金河南省郑州市技术研究与开发基金资助项目(074SGYS33193)

关键词压力性尿失禁基质金属蛋白酶组织基质金属蛋白酶抑制剂 stress urinary incontinence matrix metalloproteinase tissue inhibitor of matrix metallop roteinase

分类号 R711.2 [医药卫生—妇产科学]

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