七氟醚对大鼠急性肠缺血再灌注损伤的保护作用被引量：3

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摘要目的探讨七氟醚对大鼠急性肠缺血—再灌注损伤的保护作用及其机制。方法SD大鼠30只,随机分为对照(S)组、缺血再灌注(IR)组和七氟醚(Sevo)组,各10只。建立大鼠急性肠IR损伤模型,2 h后分别检测其血清IL-6、TNF-α及血浆超氧化物歧化酶(SOD)、丙二醛(MDA),同时观察肠组织的病理变化。结果与S组相比,IR组和Sevo组血清IL-6、TNF-α水平明显上升(P均<0.01),但Svo组IL-6、TNF-α低于IR组(P<0.05);缺血再灌注后,IR组血浆SOD活力降低、MDA升高(P均<0.01),Sevo组SOD活力、MDA分别高于和低于IR组(P均<0.05),Sevo组肠组织病理损伤分级明显低于IR组(P<0.05)。结论七氟醚对大鼠肠IR损伤有一定的保护作用,可能是通过抑制炎症介质的释放和抗氧自由基反应发挥作用。

作者丁永波马加海李爱芝王明山

机构地区青岛大学医学院附属烟台毓璜顶医院青岛市市立医院东院

出处《山东医药》 CAS 北大核心 2009年第42期34-35,共2页 Shandong Medical Journal

基金山东省烟台市科技发展计划基金资助项目(2007139-13)

关键词七氟醚小肠缺血再灌注损伤

分类号 R971.2 [医药卫生—药品]

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参考文献6

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二级参考文献21

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