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N-乙酰半胱氨酸对大鼠肝脏缺血再灌注损伤的保护作用 被引量：2

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摘要 目的探讨大鼠肝脏缺血再灌注损伤(HIRI)的机制及N-乙酰半胱氨酸(NAC)对肝组织的保护作用。方法将大鼠分成假手术组、HIRI组和NAC干预组,于再灌注1、3、6、12 h分别采用全自动生化分析仪测定各组血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)水平;黄嘌呤氧化酶法测定肝组织中超氧化物岐化酶(SOD)活性;免疫组织化学技术检测肝组织中肿瘤坏死因子α(TNF-α)表达。结果HIRI组肝脏损伤较假手术组更加明显,其中以再灌注6 h损伤最严重;血清AST、ALT均较假手术组明显升高;肝组织SOD活性明显低于假手术组(P<0.01),于再灌注6 h最低;肝组织TNF-α表达明显高于假手术组(P<0.01),于再灌注6 h达高峰。结论NAC对大鼠HIRI有保护作用,其机制与NAC清除氧自由基、减少细胞因子和炎症介质表达有关。
作者 张勇 李玺 郝林 鲍红光
机构地区 南京医科大学附属南京第一医院 徐州医学院附属淮海医院 东南大学医学院附属徐州医院
出处 《山东医药》 CAS 北大核心 2009年第41期31-32,共2页 Shandong Medical Journal
关键词 N-乙酰半胱氨酸 再灌注损伤 肿瘤坏死因子Α 肝脏
分类号 R657.3 [医药卫生—外科学]
  • 相关文献

参考文献8

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共引文献2

同被引文献28

  • 1李延玲,张怀宏,翟玉峰.益生菌对肝硬化大鼠肝细胞凋亡的干预作用[J].中国老年学杂志,2014,34(3):708-710. 被引量：5
  • 2虞希冲,陈醒言,周红宇,林丹,朱桐君.N-乙酰半胱氨酸和氯胺酮联用对脑缺血再灌注损伤的影响[J].中国临床药理学与治疗学,2005,10(4):428-431. 被引量：6
  • 3梁松岚,梁庆成,陈立杰.N-乙酰半胱氨酸对大鼠局部脑缺血再灌注损伤的保护作用[J].中国临床康复,2006,10(2):117-119. 被引量：4
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引证文献2

二级引证文献4

山东医药
2009年 第41期

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