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151例异基因造血干细胞移植急性移植物抗宿主病的临床研究 被引量：2

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摘要 目的分析造血干细胞来源、人白细胞抗原(HLA)配型、移植方式、预处理方案与急性移植物抗宿主病(aGVHD)的关系,为临床治疗选择最佳方案,降低aGVHD的发生率和严重程度。方法对151例异基因造血干细胞移植患者的临床资料进行统计学分析。结果亲缘与非亲缘之间、HLA配型之间、骨髓移植与外周血造血干细胞移植之间的aGVHD发生率有统计学差异(P<0.05);有无全身照射(TB I)的预处理方案之间的aGVHD发生率无统计学差异(P<0.05)。结论非血缘关系、HLA配型不全相合的骨髓移植是aGVHD发生的主要危险因素。
作者 葛林阜 余喆 周芳 刘希民 黄宁 解琳娜 孔凡盛 方圆 王彬
机构地区 济南军区总医院 安斯泰来制药有限公司
出处 《山东医药》 CAS 北大核心 2009年第41期75-77,共3页 Shandong Medical Journal
关键词 造血干细胞移植 异基因 移植物抗宿主病 人白细胞抗原
分类号 R733 [医药卫生—肿瘤]
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参考文献5

  • 1Reddy V, Hill GR, Pan L, et al. G-CSF modulates cytokine profile of dendritic cells and dicreases acute graft-versus-host disease through effects on the donor rather than the recipient [ J ]. Transplantation, 2000, 69(4) :691-693.
  • 2陈瑶,陆道培,刘开彦,董陆佳,任汉云,黄晓军,陈欢,刘代红,江倩,陈育红,许兰平,张耀臣,路瑾,高志勇.异基因造血干细胞移植后急性移植物抗宿主病151例危险因素分析[J].中华血液学杂志,2005,26(2):74-77. 被引量：29
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二级参考文献18

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共引文献46

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二级引证文献13

山东医药
2009年 第41期

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