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ALOX5启动子区变异位点基因型变异与白三烯拮抗剂抗哮喘疗效的关系 被引量：3

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摘要 目的研究中国正常人群和哮喘人群5-脂氧化酶(ALOX5)基因启动子区变异位点基因型变异频率及其与白三烯拮抗剂治疗效果的关系。方法按随机抽样原则选择白三烯拮抗剂治疗有效(A组)与无效(B组)病例各50例及正常人100例,测定入选者治疗前后第1秒用力呼气容积/肺活量(FEV1/FVC);抽取10ml全血,检测Sp1-Egr1等位基因型基因序列。结果A组FEV1/FVC治疗前后比较有统计学差异(P<0.05);治疗后A组与B组FEV1/FVC比较有统计学差异(P<0.05);A组与B组比较ALOX5启动子处的Sp1-Egr1基因多态性有显著统计学差异(P<0.01)。结论中国人群ALOX5基因启动子变异与白三烯拮抗剂治疗哮喘患者的疗效相关,ALOX5基因启动子基因序列检测可以指导哮喘患者的临床用药。
作者 周奇兴 朱峥 邹盈
机构地区 上海市普陀区利群医院
出处 《山东医药》 CAS 北大核心 2009年第45期37-38,共2页 Shandong Medical Journal
关键词 哮喘 ALOX5基因 核心启动子区 白三烯拮抗剂
分类号 R562.2 [医药卫生—呼吸系统]
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参考文献9

  • 1In KH, Asano K, Beier D, et al, Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription [ J ]. J Clin Invest, 1997,99(5) :1130-1137.
  • 2支气管哮喘防治指南[J].中华结核和呼吸杂志,1997,20(5):261-267. 被引量：2006
  • 3Noonan MJ, Chervinsky P, Brandon M. Montelukast:a potent leukotriene receptor antagonist , causes dose related improvements in chronic asthma. Montelukast Asthma Study Group [ J ]. Eur Respir, 1998,11(6) : 1232-1239.
  • 4Obase Y, Shimoda T, Tomari S, et al. Effects of pranlukast on aspirin-induced bronehoeonstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients [ J ]. Ann Allergy Asthma Immunol, 2001,87( 1 ) :74-79.
  • 5梁永杰,蔡映云.白三烯受体拮抗剂对喘息型慢性支气管炎的疗效[J].上海医学,2004,27(3):206-207. 被引量：6
  • 6Koshino T, Takano S, Houjo T, et al. Expression of lipoxygenase and 5-lipoxygenase activating protein mRNAs in the peripheral blood leukocytes of asthmatics [ J ]. Biochem Biophys Res Commun, 1998,2(47) :510-513.
  • 7Manev H. 5-Lipoxygenase gene polymorphism and onset of alzheimer' s disease [ J ]. Medical Hypotheses, 2006,66 ( 3 ) : 501-503.
  • 8潘明鸣,孙铁英.参与白三烯合成的酶基因多态性与支气管哮喘[J].中华结核和呼吸杂志,2004,27(9):621-623. 被引量：4
  • 9路智红,宋俊峰,李玉琴.5-脂氧合酶在哮喘发病机制及治疗中作用的研究进展[J].中国实用儿科杂志,2007,22(4):315-317. 被引量：9

二级参考文献32

  • 1Yang-meiDENG Qiang-minXIE Shui-juanZHANG Ji-qiangCHEN Qiu-huoYANG Ru-lianBIAN.Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats[J].Acta Pharmacologica Sinica,2005,26(3):353-358. 被引量：5
  • 2Vogel J Smidt. Impulse osillometry, pmi Verlagsgnippe GmbH,Frankfurt am Main 1994.
  • 3Muller E, Vogel J. Modelling and parameter estimation of the respiratory system using oscillatory impedance curves. Bull Eur Physiopath Resp, 1981, 17: P10-P17.
  • 4Bisgaard H, Klug B. Lung function measurement in awake young children. Eur Respir J, 1995, 8: 2067-2075.
  • 5Mahler DA, Weinberg DH, Wells CK, et al. The measurement of dyspnea. Chest, 1984, 85: 751-758.
  • 6Noseda A, Carpiaux J, Schmerber J, et al. Dyspnoea assessed by vi,saul analogue scale in patiants with chronic obstructive lung disease during progressive and high intensity exercise. Thorax, 1992,47: 363-368.
  • 7Altose MD. Assessment and management of breathlessness. Chest,1985, 88(2 suppl): S77-S88.
  • 8Noonan MJ,Chervinsky P,Brandon M. Montelukast,a potent leukotriene receptor antagonist,causes dose-related improvements in chronic asthma. Montelukast Asthma Study Group.Eur Respir J,1998,11: 1232-1239.
  • 9Obase Y,Shimoda T,Tomari S,et al. Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. Ann Allergy Asthma Immunol, 2001,87: 74-79.
  • 10He JQ, Joos L, Sandford AJ. Recent developments in the genetics of asthma. Pharmacogenomics, 2001, 2: 329-339.

共引文献2019

同被引文献37

  • 1潘明鸣,孙铁英,张洪胜.白三烯C_4合成酶-A_(-444)C基因多态性与支气管哮喘关系的研究[J].中国呼吸与危重监护杂志,2007,6(3):180-184. 被引量：6
  • 2胡亚美 江载芳.诸福棠实用儿科学[M]第7版[M].北京:人民卫生出版社,2002.1514.
  • 3Sigurs N, Gustafsson PM, Bjarnason R, et al. Severe respira- tory syncytial virus bronchiolitis in infancy and asthma and al- lergy at age 13 [J] . Am J Respir Crit Care Med, 2005, 171 (2): 137-141.
  • 4De Brasi D, Pannuti F, Antonelli F, et al. Therapeutic ap- proach to bronchiolitis: why pediatricians continue to overpre- scribe drugs? [J]. Ital J Pediatr, 2010, 3 (36) : 67.
  • 5Van Sambeek R, Stevenson DD, Baldasaro M, et al. 5" flan-king region pol ymorphism of the gene encoding leukotriene CA synthase does not correlate with the aspirin - intolerant asthma phenotype in the United States [J] . J Allegry Clin lmmunol, 2000, 106 (1 pt 1): 72-76.
  • 6Sigurs N, Bjarnason R, Sigurbergsson F, et al. Respiratory syncytial virus bronchiolitis in infancy is an important risk fac- tor for asthma and allergy at age 7 [ J ] . Am J Respir Crit Care Med, 2000, 161 (5): 1501-1507.
  • 7Hull J, Ackerman H, Isles K, et al. Unusual haplotypic structure of IL - 8, a susceptibility locus for a common respir- atory virus [J] . Am J Hum Genet, 2001, 69 (2) : 413 - 419.
  • 8Choi EH, Lee H J, Yoo T, et al. A common haplotype of in- terleukin- 4 gene IL- 4 is associated with severe respiratory syncytial virus disease in Korean children [ J ] . J Infect Dis, 2002, 186 (9); 1207-1211.
  • 9Wilson J, Rowlands K, Rockeet K, et al. Genetic variation at the IL - 10 gene locus is associated with severity in infants with severity of respiratory syncytial virus brochiolitis [ J ] . J Infect Dis, 2005, 191 (10) : 1705 - 1709.
  • 10Dimova- Yaneva D, Russell D, Main M, et al. Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis [ J ] . Clin Exp Aller- gy, 2004, 34 (4): 555-558,.

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二级引证文献12

山东医药
2009年 第45期

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