丁基苯酞衍生物的红外与拉曼光谱研究

IR and Raman Spectroscopic Studies on the Derivatives of Butylphthalide

丁基苯酞是我国脑血管领域第一个拥有自主知识产权的一类新药,常温下为一种淡黄色或者无色粘稠油状液体,具有众多优点,但在临床使用中会出现转氨酶升高、肝功能异常和消化道反应等不良反应。将卤素原子引入到丁基苯酞的6位,获得了3个固态的丁基苯酞类似物,并对其进行了IR和Raman光谱测定。两种光谱提供了互为补充的信息,引入卤原子后,双取代苯环的特征峰消失,出现了三取代苯环的特征峰。在红外中比较弱甚至检测不到的3位C—H伸缩振动在Raman中非常明显,在Raman的低波数区间检测到了可被指认为—C—C—C—C的变形振动。根据这两种光谱的研究结果确认了所合成化合物的结构。

dl-NBP is a potentially beneficial and promising drug for treatment of ischemic stroke with multiple actions that affect different pathophysiologic processes, such as improving microcirculation, decreasing brain infarct volume, regulating energy metabolism, and especially inhibiting platelet aggregation and reducing thrombus formation. However, NBP is limited to use in the clinic by other side effects, such as elevated aminotransferase, abnormal liver function and digestive response. Some derivates ofNBP were synthesized with the halides （F, Cl and Br） on the 6-position, and their IR and Raman spectra were measured. They proved the complemental information for deducing their structure. By comparing the spectra of the NBP, the band of disuhstituted benzene disappeared in the derivatives, and the band of trisubstituted benzenes were observed. The stretching vibrational band of C-H was detected in the Raman spectra, but was not observed in IR. In the low frequency region, the deformation vibration band of -C-C-C was also observed in the Raman spectra.