黄连素对颈动脉粥样硬化斑块的干预研究

The study of the effect and mechanism of berberine on the carotid atherosclerotic plaque

目的探讨黄连素对颈动脉粥样硬化斑块干预的效果及机制。方法将92例伴有颈动脉粥样硬化斑块的缺血性脑血管病患者随机分成研究组及对照组;研究组口服黄连素,对照组口服氟伐他汀;于治疗前、治疗后2及4个月进行颈动脉超声检查,测量颈动脉TMT、颈动脉粥样硬化斑块面积及数量,以及检查治疗前、治疗后2及4个月sICAM-1、sVCAM-1、sE-selectin数值。结果与治疗前相比,治疗后4个月2组颈动脉IMT及颈动脉粥样硬化斑块面积、数量减小,差异有显著性(P<0.05),2组之间差异无显著性(P>0.05)。与治疗前相比,治疗后2组sICAM-1、sVCAM-1、sE-selectin均降低,有显著差异(P<0.05),2组之间差异无显著性(P>0.05)。结论黄连素可用于治疗颈动脉粥样硬化斑块,从而可应用于缺血性脑血管病的二级预防。

Objective To explore the effect and mechanism of berberine on the carotid atherosclerotic plaque （AP）. Methods 92 patients with ischemic cerebrovascular diseases were randomly divided into two groups： Investigation group and control group. Investigation group received herherine, while the control group received simvastatin. The intima midia thickness （IMT） of carotid artery, the area of carotid atherosclerosis plaque, and the number of AP were measured before treatment,after 2 and 4 months of treatment respectively. sICAM-1, sVCAM-1 and sE-selectin are detected correspondingly. Results Compared with before treatment and control group, after 4 months of treatment, the IMT of carotid artery, the area of carotid AP the number of AP, the expression of sICAM-1,sVCAM-1 ,sE-selectin, significantly reduced in the investigation group （P 〈0. 05）. There was no significant difference in the incidence rates of cerebrovascular event between the two groups （P〉0. 05）. Conclusions Berberina can be therapeutic to the carotid atherosclerosis plaque and utilized in second prevention in ischemic strokes.