6Pitt B, Remme W,Zannad F, et al. Eplerenone a selective aldosterone blocker in patients with left ventricular dysfunction after myocardial infarction [ J ]. N Engl J Med,2003,348 : 1309 - 1321.
7Juurlink DN, Mamdani MM ,Lee DS ,et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med,2004,351:543 -551.
9Gregg C. Fonarow,MD,et al. Effects of carvedilol early after myocardial infarction:Analysis of the first 30 days in Carvedilol Post -infart Survival Control in Left Ventricular Dysfunction [ J ]. Amerrican Heart J October,2007,154:637 - 644.
10Packer M,Coats AJ,Fowler MB,et al. Effect of carvedilol on survival in severe chronic heart failure[J]. N Engl J Med,2001, 344:1651 - 1658.
2Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med,1999,341:709-1717.
3Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med,2003,348:1309-1321.
4Silvestre JS, Robert V, Heymes C, et al. Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. J Biol Chem, 1998,273:4883-48891.
5Mizuno Y, Yoshimura M, Yasue H, et al. Aldosterone production is activated in failing ventricle in humans. Circulation, 2001,103:72-77.
6Young MJ, Clyne CD, Cole TJ, et al. Cardiac steroidogenesis in the normal and failing heart. J Clin Endocrinol Metab, 2001,86:5121-5126.
7McMahon EG.Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr Opin Pharmacol, 2001,1:190-196.
8Brilla CG, Pick R, Tan LB, et al. Remodeling of the rat right and left ventricles in experimental hypertension.Circ Res, 1990,67:1355-1364.
9Brilla CG, Weber KT. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat. Cardiovasc Res,1992,26:671-677.
10Brilla CG, Zhou G, Matsubara L, et al. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol,1994,26:809-820.