CDK4蛋白表达在口腔癌预后中的意义

Prognostic Significance of CDK4 Protein Expression in Patients with Oral Cancer

目的检测CDK4在口腔鳞状细胞癌(OSCC)中的表达及其与预后的关系。方法档案病理标本由48例OSCC组织构成。所有病例均行外科手术治疗并被分为两组:化疗组24例及单纯手术组24例。所有组织标本行CDK4蛋白免疫组织化学染色。标记指数(LI)代表阳性细胞率。结果虽然CDK4LI与淋巴结转移无关,但无论化疗者还是单纯手术者CDK4的低表达均与良好预后有关(P<0.05;P<0.005)。结论CDK4在OSCC内的表达可能具有预后意义。

Objective To examine the expression pattern of CDK4 in oral squamous cell carcinoma （OSCC） and its relation to survival.Methods Archival pathological specimens consisted of 48 cases of OSCC.All the cases underwent surgical operation and were classified into 2 groups：twenty-four cases with chemotherapy and 24 cases with surgery alone.Histological specimens for diagnosis obtained from surgical operation underwent immunohistochemical staining for CDK4 protein.Labeling index （LI） was presented by the percentage of positive cells. Results Although CDK4： LI did not significantly correlate with lymph nod metastasis, low CDK4 expression significantly correlated with favorable survival outcome in either the cases with chemotherapy or the cases with surgery alone （P〈0. 05; P〈0. 005）. Conclusion CDK4 expression may have prognostic significance in OSCC.