卵巢癌^(99m)Tc-MIBI显像与化疗疗效的相关性

Correlation Between ^(99m)Tc-MIBI Scintigraphy of Ovarian Cancer and Efficacy of Chemotherapy

目的探讨卵巢癌99mTc-MIBI显像与化疗疗效的关系及临床意义。方法对28例卵巢癌复发患者进行99mTc-MIBI显像,采集10min及60min两时相的平面像,采用感兴趣区(ROI)技术计算早期和延迟相肿瘤/非肿瘤(T/N)比值及滞留指数(RI);采用TP方案进行化疗,并与T/N、滞留指数进行相关性分析。结果T/N比值及滞留指数低者,对化疗不敏感;T/N比值高、滞留指数高者,化疗有效,差异有统计学意义。结论99mTc-MIBI亲肿瘤显像能预测卵巢癌化疗敏感性,为临床个体化治疗提供理论依据。

Objective To evaluate the relationship between the 99mTc-MIBI Scintigraphy of ovarian cancer and the efficacy of chemotherapy.Methods Twenty-eight patients with advanced ovarian cancer underwent 99mTc-MIBI cintigraphy.Static planar images were taken at 10 min and 60 min after scintigraphy.Meanwhile technique of region-of-interest （ROI） was used to calculate T/N and retention indices of 99mTc-MIBI.Each patient received chemotherapy of TP.Results The patients with low T/N and low retention indices had poor efficacy of chemotherapy. The patients with high T/N and high retention have good efficacy of chemotherapy. There was significant difference between two groups. Conclusion The 99mTc-MIBI Scintigraphy may be used to evaluate the efficacy of chemotherapy in ovarian cancer, and thus can offer theoretical basis for individual therapy.