APC联合冷冻治疗53例中央型肺癌

Combination of Argon Plasma Coagulation and Cryotherapy in Treatment of Central Type Lung Cancer

目的探讨经支气管镜氩等离子体凝固(argon plasma coagulation,APC)结合冷冻治疗中央型肺癌的疗效及安全性。方法经支气管镜对53例中央型肺癌患者进行APC结合冷冻治疗,其中非小细胞肺癌(NSCLC)46例,小细胞肺癌(SCLC)7例,从症状改善情况、肺功能、血气分析、气促评分、体力状况变化、狭窄再通疗效等方面进行评价。结果53例病人经136次治疗后完全有效29例(54.7%)、部分有效21例(39.6%)、轻度有效2例(3.8%)、无效1例(1.9%)。仅有少数病例出现一过性轻、中度低氧血症(19.9%)。结论经支气管镜应用APC结合冷冻治疗中央型肺癌安全、有效。

Objective To evaluate the effectiveness and safety of using argon plasma coagulation （APC） combined with cryotherapy via bronchoscopy in the treatment of central type lung cancer.Methods Overall 53 patients,including 46 cases of NSCLC,7 cases of SCLC with central type lung cancer were selected and treated with APC combined with cryotherapy via bronchoscopy.The evaluation includes the changes of the symptoms,pulmonary function,blood gas analysis,dyspnea index,the KPS scores and the degree of airway obstruction. Results Full effectiveness was achieved in 29 cases（54. 7%） ,partially in 21 cases（39. 6%） ,mildly in 2 cases（3. 8%）and none in 1 case（1.9%）. Only a few cases experienced mild to moderate hypoxemia transiently（ 19. 9%）. Conclusion The method of APC combined with cryotherapy is effective and safe in the treatment of central type lung cancer.