慢性阻塞性肺疾病急性加重期患者血清中IL-18水平

Changes of Serum IL-18 Level in Patients of Chronic Obstructive Pulmonary Disease with Acute Exacerbation before and after the Treatment,and Its Significance

目的:探讨慢性阻塞性肺疾病(COPD)急性加重期患者治疗前后血清中IL-18的变化及意义。方法:采用双抗体夹心ELISA法,对45例COPD急性加重期患者治疗前后血清中IL-18进行检测,选取15例正常人做为对照组。结果:COPD急性加重期患者治疗前血清中IL-18水平明显高于治疗后及对照组,治疗后血清IL-18水平仍高于对照组。结论:IL-18参与了COPD的发生发展过程,持续升高的IL-18可能是造成COPD患者气道炎症迁延不愈的重要原因。

Objective：To investigate the changes and significance of serum IL-18 level in patients of chronic obstructive pulmonary disease（COPD）with acute exacerbation before and after the treatment.Methods：The serum IL-18 levels of 45 COPD patients with acute exacerbation and 15 healthy people（control）were determined by using double-antibody sandwich enzyme-linked immunosorbent assay.Results：The serum IL-18 levels of COPD group before the treatment were significantly higher than those after the treatment,and both were higher than those of control group.Conclusions：IL-18 contributes to the development of COPD and its continuous high level may be one of the important factors resulting in chronic airway inflammation.