不同干预方法治疗膝关节骨性关节炎的临床研究

Clinical study of different intervention treatment of knee osteoarthritis

目的对比膝关节骨性关节炎不同干预方法的疗效。方法选择诊断为膝骨性关节炎的患者共120例128关节,分为三组:关节腔内注射透明质酸钠治疗组(SH组)、关节内注射透明质酸钠的同时口服硫酸氨基葡萄糖治疗组(GS组),关节镜下关节清理术组(AD组)。比较三组治疗后的lysholm膝关节功能评分。结果三组治疗前后膝关节功能评分均有明显改善。治疗1个月时,AD组膝关节功能评分改善明显优于SH组和GS组(P<0.05);治疗6个月时,AD组与GS组无明显差异,但均优于SH组(P<0.05)。结论对于中重度患者首选方案应为关节镜清理术,有经济承受能力的患者可同时配合口服硫酸氨基葡萄糖或关节内注射透明质酸钠治疗。

Objective To compare the knee joint osteoarthritis efficacy of different interventions.Methods The diagnosis of patients with knee osteoarthritis a total of 120 patients with 128 joints,were divided into three groups：intra-articular injection of hyaluronic acid treatment group（SH group）,intra-articular injection of sodium hyaluronate at the same time oral glucosamine sulfate the treatment group（GS group）,arthroscopic joint debridement group（AD group）.Comparing the three groups after treatment lysholm knee function scores.Results the knee joint function score showed significant improvement in the three groups after treatment.1 month after treatment,AD Group＇s knee function score improved significantly better than the SH group＇s and the GS group＇s（P〈0.05）,treatment for 6 months,AD group and the GS group was no significant difference,but all better than the SH group（P〈0.05）.Conclusion For patients with moderate to severe preferred solution should be arthroscopic debridement,there is the affordability of the patients may be at the same time of oral glucosamine sulfate or sodium in the treatment of intraarticular injection of hyaluronic acid.