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侧群细胞分析法在脑肿瘤干细胞研究中的应用及其局限性 被引量：2

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摘要 目前，用来分选和培养肿瘤干细胞（TSCs）的方法主要有两种：一种是利用特异性的细胞表面标记物，例如CD133分选胶质瘤干细胞（GSCs），但该方法不能用于那些缺乏已知标记物的肿瘤细胞，且正常干细胞标记物不一定是肿瘤干细胞标记物；另一种是利用肿瘤干细胞在特定培养基中悬浮生长形成干细胞球的特性，特异性富集肿瘤干细胞。除此之外，还有一种方法是侧群细胞（SP）分析法，
作者 高宝成 万锋 陈坚 雷霆
机构地区 华中科技大学同济医学院附属同济医院神经外科
出处 《中国现代神经疾病杂志》 CAS 2009年第6期535-538,共4页 Chinese Journal of Contemporary Neurology and Neurosurgery
基金 国家自然科学基金-青年科学基金资助项目(项目编号:30801177)
关键词 脑肿瘤 神经胶质瘤 肿瘤干细胞 综述文献
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1董军.对脑肿瘤干细胞五年研究历程的反思及再认识[J].中国现代神经疾病杂志,2008,8(5):384-387. 被引量：6
  • 2Wu C, Alman BA. Side population cells in human cancers. Cancer Lett, 2008, 268:1-9.
  • 3Patrawala L, Calhoun T, Schneider-Broussard R, et al. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2 + and ABCG2- cancer cells are similarly tumorigenic. Cancer Res, 2005, 65:6207-6219.
  • 4Goodell MA, Brose K, Paradis G, et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med, 1996, 183:1797-1806.
  • 5Bleau AM, Hambardzumyan D, Ozawa T, et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell, 2009, 4: 226-235.
  • 6Srivastava VK, Nalbantoglu J. Flow cytometric characterization of the DAOYmedulloblastoma cell line for the cancer stem-like phenotype. Cytometry A, 2008, 73:940-948.
  • 7Wu C, Wei Q, Utomo v, et al. Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. Cancer Res, 2007, 67:8216-8222.
  • 8Chua C, Zaiden N, Chong KH, et al. Characterization of a side population of astrocytoma cells in response to temozolomide. J Neurosurg, 2008, 109:856-866.
  • 9Kondo T, Setoguchi T, Taga T. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA, 2004, 101:781-786.
  • 10Harris MA, Yang H, Low BE, et al. Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res, 2008, 68:10051-10059.

二级参考文献24

  • 1[1]Singh SK,Clarke ID,Terasaki M,et al.Identification of a cancer stem cell in human brain tumors.Cancer Res.2003.63:5821-5828.
  • 2[2]Singh SK,Hawkins C,Clarke ID,et al.Identification of human brain tumour initiating cells.Nature.2004,432:396-401.
  • 3[3]Singh SK,Clarke ID,Hide T,et al.Cancer stem cells in nervous system tumors.Oncogene,2004,23:7267-7273.
  • 4[4]Galli R.Binds E,Orfanelli U,et al.Isolation and characterization of tumorigenic.stem-like neural precursors from human glioblastoma.Cancer Res.2004.64:7011-7021.
  • 5[5]Yao Y,Wang X,Jin K,et al.B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells.J Neurooncol,2008.89:121-129.
  • 6[6]Dirks PB.Brain tumor stem cells.Biol Blood Marrow Transplant,2005.11(2 Suppl 2):12-13.
  • 7[7]Eramo A,Ricci-Vitiani L,Zeuner A,et al.Chemotherapy resistance of glioblastoma stem cells.Cell Death Differ,2006,13:1238-1241.
  • 8[8]Cancer Institute and Hospital,Chinese Academy of Medical Sciences,Proceedings of the First International Symposium on Cancer Stem Cells.Hangzhou,China,2007,Hangzhou:University of Zhejiang Press,2007.
  • 9[9]Gleiberman AS.Michurina T,Encinas JM,et al.Genetic approaches identify adult pituitary stem cells.Proc Natl Acad Sci USA.2008.105:6332-6337.
  • 10[10]Levy A.Stem cells,hormones and pituitary adenomas.J Neuroendocrinol.2008.20:139-140.

共引文献5

同被引文献35

  • 1傅相平,李安民,张志文,闫润民,易林华,刘爱军.^(131)I-肿瘤细胞核人鼠嵌合单抗脑胶质瘤瘤内放免治疗研究[J].中华实验外科杂志,2005,22(1):102-103. 被引量：12
  • 2王东海,李新钢,王英,曲迅,李刚,宫崧峰,刘泉萌,鲍修风.DC/C6融合瘤苗防治C6胶质瘤的实验研究[J].中国病理生理杂志,2007,23(2):254-257. 被引量：2
  • 3国家自然科学基金委员会.国家自然科学基金条例.2007-02-04.
  • 4Hopkins K, Chandler C, Eatough J, et al. Direct injection of 90Y MoAbs into glioma tumor resection cavities leads to limited diffusion of the radioimmunoconjugates into normal brain parenchyma: a model to estimate absorbed radiation dose [J]: Int J Radiat Oncol Biol Phys, 1998, 40(4): 835- 844.
  • 5Freije WA, Castro-Vargas FE, Fang Z, et al. Gene expression profiling of gliomas strongly predicts survival [J]. Cancer Res, 2004, 64(18): 6503-6510.
  • 6Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I1. Functional properties in vitro [J]. J Exp Med, 1974, 139(2): 380-397.
  • 7Hart DN, Hill GR. Dendritic cell immunotherapy for cancer: application to low-grade lymphoma and multiple myeloma [J]. Immunol Cell Biol, 1999, 77(5): 451-459.
  • 8Hsu FJ, Benike C, Fagnoni F, et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulseddendritic cells [J]. Nat Med, 1996, 2(1): 52-58.
  • 9Liau LM, Black KL, Prins RM, et al. Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens [J]. J Neurosurg, 1999, 90(6): 1115- 1124.
  • 10Yu JS, Wheeler C J, Zehzer PM, et al. Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration [J]. Cancer Res, 2001, 61(3): 842-847.

引证文献2

二级引证文献28

中国现代神经疾病杂志
2009年 第6期

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