2005～2007年泰安市部分高中毕业生乙型肝炎血清标志物调查

Analysis of Serological Markers of HBV in Senior High School Graduates in Tai'an City of 2005-2007

[目的]探讨本市青年学生人群中乙型肝炎病毒(HBV)的感染状况和乙型肝炎五项血清标志物的模式特征。[方法]用酶联免疫吸附试验(ELISA)测定部分学生血清中乙型肝炎病毒表面抗原(HBsAg)及其抗体(HBsAb)、e抗原(HBeAg)及其抗体(HBeAb)以及核心抗体(HBcAb)五项HBV血清标志物(HBVM)。[结果]2 552人中1 456例为全阴性,占57.05%;1 096例为HBVM五项中有一项或一项以上阳性,总阳性率为42.95%,模式共有12种,分为感染期模式组和恢复期模式组,感染期模式组以"135"和"145"模式为主;恢复期模式组以"2"、"5"和"25"模式为主。[结论]在本市青年学生人群中,乙肝的总感染率仍较高,应加强乙型肝炎的防治和乙肝病毒的检测。

[Objective]To explore the infection of hepatitis B virus（HBV） and the different patterns of five serological markers in students.[Methods]HBsAg,HBsAb,HBeAg,HBeAb,HBcAb were detected in serum samples from the students by enzyme-linked immunosorbent assay.[Results]The result was negative in 1 456 cases,accounting for 57.05% of the total 2 552 cases,and result of 1 item or more than 1 item was positive in 1 096 cases,accounting for 42.95% of the total cases.There were 12 different patterns in all which could be divided into infection pattern group and recovery pattern group.The pattern ＂135＂and ＂145＂ were primary in the infection pattern group and pattern ＂2＂ 、＂5＂ and ＂25＂ were primary in the recovery pattern group.[Conclusion]The total rate of HBV infection was still high among youth students in Tai＇an city and the prevention and testing of hepatitis B should be enhanced.