病证结合动物模型对中医药研究的意义及建模方法新思路

Significance of animal model of combined disease and syndrome in TCM research and new train of thoughts in establishing models

证候动物模型在中医证候以及中药药理研究中都有着重要的意义,其发展水平的滞后已经成为中医药现代化的瓶颈;以目前的研究水平来看,病证结合的动物模型是最适合中医药研究的技术平台,在研究中,通过流行病学调查和无监督方法,建立疾病的证候诊断标准,可以保证纳入病例的客观性;以此为标准,从多种病证结合动物模型建立方法中选择出与临床最吻合的一种,再通过方证相应("证实")及方证相左("证伪")对动物模型的疗效反证,评价其可靠性,这种建立病证结合动物模型的思路与方法,既以中医理论为指导,又能够用科学的实验方法去证实,将为疾病实验研究及中药临床疗效评价提供依据。

The animal model of syndrome had significance in studying traditional Chinese medical （TCM） syndrome and TCM pharmacology. Its lagging already became the bottleneck of TCM modernization. At present, animal model of combined disease and syndrome is the most suitable technological platform for TCM research. In order to ensure objectivity of the illness cases brought into research, we should establish TCM syndrome criteria by epidemiological methods. Taking this as standard, a kind of animal model should be selected, which coincides with the clinic situation of the patients. Then, we should evaluate reliability of this animal model by demonstrating the curative effect. This thought and method was not only guided by TCM theory and verified by experimental methods. It might be the basis of disease experimental research and evaluating the clinic effect of TCM.