银杏叶提取物EGB761对高胆固醇家兔肝质量和形态的影响

Effect of ginkgo biloba extract EGB761 on liver weight and morphology in hypercholesterolemia rabbits

[目的]观察银杏叶提取物(EGB761)对高胆固醇家兔肝质量和形态的影响。[方法]参照D.Larry Sparks等方法复制高胆固醇血症家兔模型。采用50mg(/kg·d)EGB761灌胃3周,以辛伐他汀5mg(/kg·d)作为阳性对照药。评价肝体指数,观察肝脏的形态学变化。[结果]EGB761可以有效降低肝体指数(P<0.01),与阳性药辛伐他汀疗效相比无显著性差异(P>0.05);大体和镜下形态学观察发现EGB761可以有效的改变脂肪变性肝脏的大体形态和组织学形态。[结论]EGB761可以有效防治高胆固醇血症所致脂肪肝的发生。

[Objective] To observe the effect of Ginkgo biloba extract EGB761 on liver weight and morphology in hypercholesterolemia rabbits. [Methods] The hypercholesterolemia in rabbit was induced by refer to D. Larry Sparks＇methods. EGB761 was used to treat the rabbits at a dose of 50mg/kg/d and simvastatin, 5mg/kg/d, as a positive control drug. The index of liver and body was evaluated and the morphological changes of the liver were observed. [Results] Ginkgo biloba extract EGB761 could effectively reduce the liver body index （P〈0.01） without significant difference compared to the effect of positive drug simvastatin （P〉0.05）. General and the microscope morphological observations found that EGB761 could effectively change the general form of fatty degeneration of the liver and histological patterns. [Conclusion] Ginkgo biloba extract EGB761 can effectively prevent and treat fatty liver induced by hypercholesterolemia.