ERCC1基因在非小细胞肺癌中的作用

Role of ERCC1 gene in non-small cell lung cancer

化疗是非小细胞肺癌治疗的主要手段之一,而耐药是影响化疗疗效的重要因素。切除修复交叉互补基因1是核苷酸切除修复的关键基因,其基因表达及基因多态性与铂类耐药存在相关性,从而影响非小细胞肺癌对化疗敏感性及疗效。

Chemotherapy is one of the principal means of combined therapy in non-small cell lung cancer, but drug resistance is the major factor that impairs the therapeutic effect. Excision repair cross-complementation group 1 （ERCC1） is the key gene for nucleotide excision repair. Its expression and polymorphisms are related to platinum resistance, which may affect the chemotherapy sensititivity and efficacy for non-small cell lung cancer.