摘要
SARA是Smad锚着蛋白,可与Smad2/3直接结合,募集Smad2/3至TGF-β受体,是TGF-β信号通路中重要的衔接蛋白。SARA通过改变Smad2和Smad3的活化水平调节TGF-β信号转导,在Smad2的活化中起至关重要的作用。SARA也能与蛋白磷酸酶1的催化亚单位(PP1c)相结合,参与Smad7介导的TGF-βI型受体(TβR-I)去磷酸化。SARA的表达水平与上皮细胞转分化及纤维化的程度密切相关,参与上皮细胞转分化的调控。靶向SARA的干预策略是治疗TGF-β介导的上皮细胞转分化及纤维化的新路径。
Smad anchor for receptor activation （SARA） is known as Smad cofactor that interacts directly with Smad2/3 and functions to recruit Shred2/3 to the TGF-β receptor. SARA plays an essential role in TGF-β-induced Smad2 activation and can modulate TGF-β signaling through regulating the activity of Smad2 and Smad3. SARA also functions as an anchor for catalytic subunit of protein phosphatase 1 （PP1 c） and may be involved in the Smad7-mediated dephosphorylation of TGF-β Type Ⅰ receptor （TβR- Ⅰ ）. The SARA expression level closely relates to the development of epithelial cell transdifferentiation and fibrosis. It participates in the modulation of epithelial cell transdifferentiation. Targeted interference of SARA may provide a new therapeutical approach to TGF-β-mediated epithelial cell transdifferentiation and fibrosis.
出处
《国际病理科学与临床杂志》
CAS
2009年第6期495-498,共4页
Journal of International Pathology and Clinical Medicine
基金
教育部博士点新教师基金(200805331002)
中南大学研究生学位论文创新项目(2009bsxt030)~~
关键词
Smad锚着蛋白
转化生长因子-Β
上皮细胞转分化
纤维化
Smad anchor for receptor activation
transforming growth factor-β
epithelial to mesenchymal transition
fibrosis
