家族性腺瘤性息肉病与高脂血症的关系

Familial adenomatous polyposis and hyperlipidemia

家族性腺瘤性息肉病(familial adenomatous polyposis,FAP)是由APC(adenomatous polyposis coli)基因突变引起的常染色体显性遗传病。高脂血症作为FAP的肠外伴随症状逐渐被关注,同时在FAP的经典模型Apc基因突变的Min小鼠上也出现了高血脂症状。本文从高脂血症、FAP以及APC基因突变的角度,阐述三者的相互联系,期望对病人的预防与治疗提供有价值的参考。

FAP is an autosomal dominant disease caused by mutations of APC gene. Recently hyperlipidemia is thought as one of the extracolonic complications of FAP and the symptoms of hyperlipidemia have been seen in the classical FAP mouse model with Apc gene mutation. The relations among hyperlipidemia, FAP and APC gene mutation are discussed extensively in this review. The purpuse is to provide the valuable information for preventing and treating the FAP patients.