摘要
C5a是3条补体途径共同裂解产生的活性产物,它具有广泛的生物学功能。目前对于它的研究主要集中在促炎活性上。然而,研究发现C5a与凝血异常亦有很重要的关系。在多种疾病中,常同时存在补体系统和凝血系统的异常。作为有着相同来源的两个生物活性系统,他们直接或间接的相互作用关系到疾病的发生、发展和转归。凝血系统的异常可以表现为凝血激活亢进、抗凝物质的削弱、纤溶系统的失衡。C5a与它们均存在一定的联系。
Complement 5a, as a common cleave product of 3 complement activation pathways, possesses wide biological activities. Current studies mainly focused on its pro-inflammatory properties. However,some studies have been shown that complement 5a was associated with coagulation disorders. Disorders of complement and coagulation system coexist in many diseases. The 2 systems share same origins and the interactions (directly or indirectly) between them are related to the occurrence, progression and prognosis of the disease. The disorders of coagulation are as follows: hyper-coagulation activation, impaired anticoagulation system, and unbalanced fibrinolytic system, which all correlatet with complement 5a.
出处
《国际病理科学与临床杂志》
CAS
2009年第6期503-506,共4页
Journal of International Pathology and Clinical Medicine
基金
广州市科委攻关引导资助项目(2007Z3-E0121)~~
关键词
补体系统
凝血系统
C5A
complement system
coagulation system
C5a